Microvesicles derived from mesenchymal stem cells: Potent organelles for induction of tolerogenic signaling

Mokarizadeh, Aram; Delirezh, Nowruz; Morshedi, A; Mosayebi, Ghasem; Farshid, Amir Abbas; Mardani, Karim

doi:10.1016/j.imlet.2012.06.001

Cited by 280 publications

(232 citation statements)

References 44 publications

Supporting

Mentioning

226

Contrasting

Order By: Relevance

“…MSC-derived EVs shuttle lipids, mRNAs (Tomasoni et al, 2013), both double-strand precursor (pre-miR) and single-strand mature microRNAs (miR) (Chen et al, 2009;Collino et al, 2010;Xin et al, 2012) and are tolerogenic (Mokarizadeh et al, 2012) and neuritogenic (Xin et al, 2012) on target cells. Systemically injected EVs from human bone marrow-derived MSCs have been shown to accelerate kidney repair in a mouse model of acute kidney injury (AKI) by inhibiting apoptosis and stimulating tubular epithelial cell proliferation.…”

Section: Signaling Through Extracellular Membrane Vesiclesmentioning

confidence: 99%

How stem cells speak with host immune cells in inflammatory brain diseases

Pluchino

Cossetti

2013

Glia

111

109

View full text Add to dashboard Cite

Advances in stem cell biology have raised great expectations that diseases and injuries of the central nervous system (CNS) may be ameliorated by the development of non-hematopoietic stem cell medicines. Yet, the application of adult stem cells as CNS therapeutics is challenging and the interpretation of some of the outcomes ambiguous. In fact, the initial idea that stem cell transplants work only via structural cell replacement has been challenged by the observation of consistent cellular signaling between the graft and the host. Cellular signaling is the foundation of coordinated actions and flexible responses, and arises via networks of exchanging and interacting molecules that transmit patterns of information between cells. Sustained stem cell graft-to-host communication leads to remarkable trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses in vivo, ultimately promoting the healing of the injured CNS. Among a number of adult stem cell types, mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs) are being extensively investigated for their ability to signal to the immune system upon transplantation in experimental CNS diseases. Here, we focus on the main cellular signaling pathways that grafted MSCs and NPCs use to establish a therapeutically relevant cross talk with host immune cells, while examining the role of inflammation in regulating some of the bidirectionality of these communications. We propose that the identification of the players involved in stem cell signaling might contribute to the development of innovative, high clinical impact therapeutics for inflammatory CNS diseases.

show abstract

Section: Signaling Through Extracellular Membrane Vesiclesmentioning

confidence: 99%

How stem cells speak with host immune cells in inflammatory brain diseases

Pluchino

Cossetti

2013

Glia

111

109

View full text Add to dashboard Cite

show abstract

“…MSC-derived extracellular vesicles are able to inhibit proliferation and induce apoptosis of activated T cells while promoting secretion of anti-inflammatory cytokines [77]. In animal and in vitro studies, MSC-derived extracellular vesicles restored Th1/ Th2 balance and induced generation of Tregs, implementing the regulatory component of the adaptive immune system [77,78]. A dose-dependent inhibitory effect of MSC-derived extracellular vesicles on B-cell proliferation, differentiation and Ig production has been reported [58].…”

Section: Anti-inflammatory (M2) Mscs Inhibit the Cell Cycle Of Cytotmentioning

confidence: 99%

“…MSC-derived extracellular vesicles mimic the proregenerative and immunomodulatory effects of cellular administration in different animal models [76•]. MSC-derived extracellular vesicles are able to inhibit proliferation and induce apoptosis of activated T cells while promoting secretion of anti-inflammatory cytokines [77]. In animal and in vitro studies, MSC-derived extracellular vesicles restored Th1/ Th2 balance and induced generation of Tregs, implementing the regulatory component of the adaptive immune system [77,78].…”

Section: Anti-inflammatory (M2) Mscs Inhibit the Cell Cycle Of Cytotmentioning

confidence: 99%

MSCS in Scenarios of Infection and Inflammation: Focus on Neonatal Diseases

Pierro

Thébaud

2016

Curr Stem Cell Rep

View full text Add to dashboard Cite

The imbalance of inflammatory and antiinflammatory responses in favor of inflammation plays a major role in the pathogenesis of many neonatal diseases. Inflammation in the perinatal period carries important longterm consequences, including neurodevelopmental and respiratory complications. Treatments able to restore immune homeostasis may reduce neonatal mortality and prevent longterm deleterious multi-organ consequences of unchecked inflammation. Mesenchymal stromal cells are a heterogenous group of progenitors cells with potent anti-inflammatory and immunomodulatory potential, among other diverse mechanisms of action. Thus, mesenchymal stromal cells (MSCs) may represent a novel and effective therapy for several neonatal diseases, potentially capable of preventing their longterm complications. This paper reviews the role of inflammation in the perinatal period and the therapeutic role of MSCs, focusing on their anti-inflammatory potential.

show abstract

“…The regenerative and immunomodulatory properties of stem cell derived exosomes could be leveraged as a treatment for serious diabetic complications such as diabetic nephropathy and CNS damage (Jiang et al 2016, Venkat et al 2017. Stem cell-derived exosomes may also be the key to protecting the pancreatic islets of type-1 diabetic (T1D) patients from autoimmune targeting, slowing the disease's progression (Mokarizadeh et al 2012, Bu et al 2015. Exosomes could also aid in the angiogenesis and survival of transplanted pancreatic islets, enhancing the efficiency and success rate of the treatment (Cantaluppi et al 2012a, Kordelas et al 2014.…”

Section: Stem Cell-derived Exosomes and Diabetes Mellitusmentioning

confidence: 99%

Stem cell-derived exosomes: a novel vector for tissue repair and diabetic therapy

Newton¹,

Kim²,

Luo³

et al. 2017

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

Exosomes are extracellular vesicles (EVs) secreted from a majority of cell types. Exosomes play a role in healthy and pathogenic intercellular interactions via the transfer of proteins, lipids and RNA. The contents and effects of exosomes vary depending on the properties of the originating cell. Exosomes secreted from some cell types, including stem cells, carry biological factors implicated in the protection, regeneration and angiogenesis of damaged tissues. Due to these properties, exosomes have attracted attention as a novel vector for regenerative therapies. Exosomes as a therapeutic tool could have applications for the treatment of many disorders characterized by chronic tissue damage. Exosomes derived from stem cells could be applied to repair or prevent damage from the complications of diabetes mellitus. The immunomodulatory and reparative properties of stem cell-derived exosomes could protect or even restore an early-stage type 1 diabetic patient's original islets from autoimmune destruction. Exosomes could also possibly suppress graft rejection of pancreatic islet transplants. Therefore, it is our recommendation that the treatment of diabetes mellitus using exosome-based therapies be further explored. Development of novel therapies using exosomes is slowed by a limited understanding of their mechanisms. This hurdle must be overcome to pave the way for clinical trials and ultimately the adaptation of exosomes as a therapeutic vector.

show abstract

Microvesicles derived from mesenchymal stem cells: Potent organelles for induction of tolerogenic signaling

Cited by 280 publications

References 44 publications

How stem cells speak with host immune cells in inflammatory brain diseases

How stem cells speak with host immune cells in inflammatory brain diseases

MSCS in Scenarios of Infection and Inflammation: Focus on Neonatal Diseases

Stem cell-derived exosomes: a novel vector for tissue repair and diabetic therapy

Contact Info

Product

Resources

About