Microvessel count is predictive of patients' survival in laryngeal squamous-cell carcinoma

Beatrice, Fabio; Giusti, Umberto; Bisciari, Tiziana; Cammarota, Raffaella; Navone, Roberto; Palestro, Giorgio; Ragona, Riccardo; Sartoris, A; Arese, Marco; Bussolino, Federico; Valente, Guido

doi:10.1002/(sici)1097-0215(19961021)69:5<426::aid-ijc13>3.0.co;2-0

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…None of our clinical parameters for the laryngeal carcinoma correlated with the MVD, which is in line with the results of several groups (7,8,11), but clearly contradicts the results of other workers (3,9,10,21,25). This discrepancy may be due to differences in the treatment of the patients.…”

Section: Discussionsupporting

confidence: 62%

Microvessel Density and Endothelial Basement Membrane Composition in Laryngeal Squamous Cell Carcinomas

Hagedorn¹,

Nerlich

2000

Acta Oto-Laryngologica

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In this retrospective study we morphometrically evaluated the density of small blood vessels (microvessel density; MVD) in laryngeal squamous cell carcinomas (SCC) in order to find out if the vascular density provides relevant information on the biology and prognosis of this tumor type. In addition, we investigated the composition of the endothelial basement membrane (BM) to analyze qualitatively the role of the major BM components during tumor-associated angiogenesis. For the immunohistochemical staining of the blood vessels we used the endothelial cell marker CD31 and the BM was analyzed by immunostaining for the major components collagen-IV, laminin-1 and perlecan. Beneath the normal mucosa a mean of 18 vessels/0.41 mm2 was found. Invasive carcinomas showed a significant increase in blood vessel density to 36.3 vessels/0.41 mm2 regardless of the degree of tumor cell differentiation. Interestingly, the highest vascular density was found beneath dysplastic, but non-invasive epithelia (45.5 vessels/0.41 mm2), particularly when associated with a strong lymphoplasmacytic cell infiltration. Statistical analysis revealed a highly significant correlation between MVD and the lymphoplasmacytic infiltrate. However, we did not find any significant correlation between MVD and other clinical/biological parameters. Qualitative analysis of the endothelial BM revealed an "earliest" occurrence of laminin-1 in the obviously newly formed vessels, while collagen IV and perlecan occur at more pronounced stages of vessel formation. There was, however, no prognostically relevant information available from endothelial BM analysis. In summary, at present we do not consider the MVD in SCC of the larynx to be a prognostic factor for the individual outcome of the patient.

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Section: Discussionsupporting

confidence: 62%

Microvessel Density and Endothelial Basement Membrane Composition in Laryngeal Squamous Cell Carcinomas

Hagedorn¹,

Nerlich

2000

Acta Oto-Laryngologica

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“…Yet, it casts a shadow on the possibility of using MVD as a prognostic factor for recurrence. Th is result was also reported by Hagedorn and Nerlich [11], Pietruszewska et al [13], and Pignataro et al [26], although other studies [9,14,27,28] have shown contradictory results.…”

Section: Discussionsupporting

confidence: 70%

Does angiogenesis have a prognostic value in squamous cell carcinoma of the larynx?

Ibrahim

El-Ebiary

Hegazy

et al. 2015

Egypt J Otolaryngol

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“…Molecular markers related to tumor neovascularization have been evaluated as a possible predictor of diseasefree survival, overall survival and response to therapy (Folkman, 1985;Klagsbrun and Soker, 1993;Alcalde et al, 1997;Beatrice et al, 1998;Aebersold et al, 2000;Linderholm et al, 2000a;Smith et al, 2000;Artese et al, 2001;Esteva et al, 2002). The most commonly evaluated angiogenic markers include the microvessel density and vascular endothelial growth factor.…”

Section: Angiogenic Factorsmentioning

confidence: 99%

Molecular markers in clinical radiation oncology

Haffty¹,

Glazer²

2003

Oncogene

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Radiation therapy plays a critical role in the management of a majority of patients diagnosed with cancer. Identification of factors that help predict which patients are at risk for relapse within the irradiated field remains an active area of investigation. Although conventional clinical and pathologic factors have been helpful in identifying risk and guiding clinical decision-making for both local and systemic management, there is clearly a need to identify additional prognostic markers, which can aid in refining our treatment strategies and improving outcomes. A substantial amount of research efforts have been devoted to identifying molecular markers for prognostic and therapeutic strategies. The recent emergence of a powerful armamentarium of molecular tools has resulted in rapid expansion of our fund of knowledge and understanding of the molecular biology underlying tumor behavior and response. While a majority of these efforts have been focused on risk factors for metastatic disease and survival, there is a rapidly growing body of literature focused on molecular factors associated with radiation resistance and locoregional failure. In this review, we summarize recent advances and the available literature evaluating molecular markers as they relate to radiation sensitivity of solid tumors. Literature regarding the potential application of expression of genes related to apoptosis, angiogenesis, cell cycle, DNA repair and growth factors will be reviewed. Some of the basic biology and laboratory evidence demonstrating how the marker relates to radiation response and available correlative clinical studies employing these markers as prognostic tools are presented. The majority of molecular markers that have potential clinical significance with respect to radiation sensitivity and local control will be highlighted.

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Microvessel count is predictive of patients' survival in laryngeal squamous-cell carcinoma

Cited by 5 publications

References 5 publications

Microvessel Density and Endothelial Basement Membrane Composition in Laryngeal Squamous Cell Carcinomas

Microvessel Density and Endothelial Basement Membrane Composition in Laryngeal Squamous Cell Carcinomas

Does angiogenesis have a prognostic value in squamous cell carcinoma of the larynx?

Molecular markers in clinical radiation oncology

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