Microvessel density as a prognostic factor in esophageal squamous cell cancer patients

Ma, Guangzhi; Zhang, Jing; Jiang, Hai; Zhang, Nannan; Zhu, Yunjie; Deng, Yunfu; Zhang, Qinghua

doi:10.1097/md.0000000000007600

Cited by 20 publications

(14 citation statements)

References 48 publications

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“…The Alder grades are mainly concentrated on the blood flow signals, which to some extent can reflect the proliferation of vessels and the characteristics of microvessel density around the cervical cancer. Previous studies [32][33][34] have reported that the blood signals may predict the ability of tumor invasion and metastasis to a certain extent, which is consistent with the results of our study.…”

Section: Plos Onesupporting

confidence: 93%

The Adler grade by Doppler ultrasound is associated with clinical pathology of cervical cancer: Implication for clinical management

Che

Yang²,

Wei

et al. 2020

PLoS ONE

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Objective To analyze the relationship of Adler grade by transvaginal color Doppler flow imaging (TV-CDFI) and the clinical pathological parameters of patients with cervical cancer, and to identify the value of Adler grade in the diagnosis and treatment of cervical cancer. Methods Patients with cervical cancer diagnosed pathologically in our hospital from January 1, 2019 to December 31, 2019 were included, All patients underwent TV-CDFI examination, and the images were divided into 0 to III grades according to the Adler grades, and the correlations between the Adler classification and clinical pathological parameters (clinical stage, mass size, pathological type, squamous cell carcinoma subtype, CA125, CA199) were analyzed. Results A total of 162 patients with cervical cancer were included. With the increase of Adler severity, the clinical stage of cervical cancer increased accordingly. the cancer size differed significantly in patients with different Adler grade (p = 0.004); There were significant differences in the level of CA125, CA199 between the squamous cell carcinoma and adenocarcinoma (all p<0.05). the Adler grade was positively related with the clinical stage, pathological type and squamous cell carcinoma subtypes of cervical cancer (all p<0.05), no correlations were found among the Adler grade and the cancer size, CA125, CA199 (all p>0.05). The area under ROC curve of the cervical squamous cell carcinoma predicted by Adler grade based on FIGO results and pathological results was 0.811and 0.762 respectively (all p<0.05). Conclusions Adler grades are closely associated with the clinical pathology of cervical cancer, which may be a convenient and effective approach for the assisting assessment of cervical cancer.

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Section: Plos Onesupporting

confidence: 93%

The Adler grade by Doppler ultrasound is associated with clinical pathology of cervical cancer: Implication for clinical management

Che

Yang²,

Wei

et al. 2020

PLoS ONE

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“…During the last 20 years, different studies recognised 'high' MVD a poor prognostic factor for cancer patients, 27–29 including women affected by OC. 30 Different biomarkers have been adopted to assess MVD in OC, including Von Willebrand Factor, CD105, CD34 and CD31, being CD34 the most used MVD detector and the biomarker associated with the poorest HR for OS (HR: 1.67, CI 95%: 1.36–2.35) compared to other MVD detectors (HR: 1.32, CI 95%: 0.82–1.82).…”

Section: Discussionmentioning

confidence: 99%

Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study).

et al. 2018

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“…[7] Currently, antibodies for staining endothelial cells of microvessel mainly include those against platelet/endothelial cell adhesion molecule CD31, pan-endothelial marker CD34, homodimeric transmembrane protein CD105, and von Willebrand Factor. [8] It has been proved that MVD is correlated with the prognosis in patients with various malignancies, including breast cancer, [9] colorectal cancer, [10] non-small cell lung cancer, [11] and so on.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of microvessel density in patients with glioma

Fan¹,

Zhang²,

Li³

et al. 2019

Medicine

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Background:The aim of this study was to systematically evaluate the prognostic role of microvessel density (MVD) in patients with glioma through performing a meta-analysis.Methods:Web of Science, EMBASE, PubMed, Cochrane Library, and China National Knowledge Infrastructure were searched for potentially relevant literature. The study characteristics and relevant data were extracted. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of MVD in patients with glioma.Results:Nine studies with 536 patients were included. The pooled HR of higher MVD for overall survival (OS) was 1.64 (95% CI, 1.07–2.50) in patients with glioma. Subgroup analyses were also performed. The pooled HRs of higher MVD in studies from East Asia studies examining high-grade gliomas and studies using anti-CD105 antibodies were 1.99 (95% CI, 1.04–3.80), 1.60 (95% CI, 1.09–2.34) and 2.99 (95% CI, 1.50–5.99), respectively. No significant publication bias was found (P = .592), but significant between-study heterogeneity was observed (I2 = 80.5%, P <.001) in the meta-analysis.Conclusion:Our results suggested that higher MVD was associated with worse OS in patients with glioma. The findings may assist future research on antiangiogenic therapy and help predict prognosis in glioma. However, due to the limited number of studies, more well-designed studies are warranted to further verify our results.

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Microvessel density as a prognostic factor in esophageal squamous cell cancer patients

Cited by 20 publications

References 48 publications

The Adler grade by Doppler ultrasound is associated with clinical pathology of cervical cancer: Implication for clinical management

The Adler grade by Doppler ultrasound is associated with clinical pathology of cervical cancer: Implication for clinical management

Characterisation of tumour microvessel density during progression of high-grade serous ovarian cancer: clinico-pathological impact (an OCTIPS Consortium study).

Prognostic role of microvessel density in patients with glioma

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