Microvessel Density in Head and Neck Squamous Cell Carcinoma Primary Tumors and Its Correlation with Clinical Staging Parameters

Lentsch, Eric J.; Goudy, Steven L.; Sosnowski, Jeffrey; Major, Scott B.; Bumpous, Jeffrey M.

doi:10.1097/01.mlg.0000195286.29613.e1

Cited by 30 publications

(19 citation statements)

References 9 publications

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“…Several studies reported strong correlation between high microvessel counts and both recurrent or metastatic disease in HNSCC [6,7]. In 2005 a meta-analysis confirmed previous data about levels of VEGF and risk of lymph node metastases (1.88-fold higher risk of death at 2 years) [8].…”

Section: Results Of Preclinical Datasupporting

confidence: 74%

Angiogenesis in Head and Neck Cancer

EG¹

2014

J Cancer Sci Ther

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Locally advanced Head and Neck Squamous Cell Carcinoma (HNC) is a challenging disease for the lack of effective therapies even in the era of molecular medicine (the five-year survival does not exceed 40%). For patients with metastatic and recurrent HNC the standard treatment is the combination of Cetuximab/Platinum and Fluorouracil but median overall survival rate for this population remains lower than 11%. The main reasons of these disappointing outcomes include acquired drug resistance, anti Epidermal growth factors variants, epithelial to mesenchymal transition and tumor hypoxia.Angiogenesis plays a crucial role in HNSCC development and proliferation. Drugs may interfere with the angiogenic process via different mechanisms and there is a sound rationale for combining anti-angiogenic agents with chemotherapy or multiple anti-angiogenic strategies. Promising preclinical results with angiogenic inhibitors have engendered a number of trials, but until now there are not yet conclusive data on the value of anti-angiogenic therapy in HNC.

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Section: Results Of Preclinical Datasupporting

confidence: 74%

Angiogenesis in Head and Neck Cancer

EG¹

2014

J Cancer Sci Ther

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“…The prognostic role of microvessel density in squamous cell carcinoma of the upper aerodigestive tract was also confirmed by other studies which reported a higher density for more advanced stages [4]. …”

Section: Introductionsupporting

confidence: 71%

The Role of Antiangiogenic Agents in the Treatment of Head and Neck Cancer

Denaro¹,

Colantonio³

et al. 2012

Oncology

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Despite progress in the treatment of locally advanced head and neck squamous cell cancer (HNSCC), the prognosis remains dismal and 5-year survival does not exceed 40%. In metastatic and recurrent disease, in spite of the introduction of cetuximab in combination with platinum and fluorouracil, the median overall survival rate remains lower than 11 months. There are many possible reasons for these disappointing results including acquired drug resistance and tumor hypoxia. Angiogenesis plays an important role in HNSCC development and proliferation. Promising preclinical results with antiangiogenic therapies have engendered a number of clinical trials, but so far there have not been any conclusive results on the value of such treatments. This paper aims to review the role of angiogenesis in head and neck cancer and to suggest future perspectives.

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“…The relationship between MVD and prognostic parameters in head and neck epidermoid carcinoma could not be completely explained [20]. In spite of studies finding a relationship between high MVD and tumor progression, tumor stage and grade, studies suggesting that there was no such relationship have also been reported [7,8,12,20-22].…”

Section: Discussionmentioning

confidence: 99%

“…In spite of studies finding a relationship between high MVD and tumor progression, tumor stage and grade, studies suggesting that there was no such relationship have also been reported [7,8,12,20-22]. Tse et al [19] conducted a study on 186 cases with head and neck epidermoid carcinomas including 34 cases with laryngeal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx

Süllü

Gün²,

Atmaca

et al. 2010

Diagn Pathol

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BackgroundThe aim of this study was to assess the relationship between expression of vascular endothelial growth factor (VEGF) and phosphatase and tensin homolog deleted in chromosome ten (PTEN), angiogenesis and clinicopathological parameters of squamous cell carcinoma of the larynx.MethodsWe examined immunohistochemical expression of VEGF and PTEN and CD34 for microvessel density (MVD) in sections of formalin-fixed, paraffin embedded tissue blocks of 140 patients with squamous cell carcinoma of the larynx. The intensity of VEGF and PTEN staining and the proportion of cells staining were scored.ResultsThe tumor grade was not significantly related to PTEN expression, but it was to VEGF expression (p = 0.400; p = 0.015, respectively). While there was no significant relationship between PTEN expression and tumor size and cartilage invasion (p = 0.311, p = 0.128), there was a significant relationship between the severity of VEGF expression and tumor size (p = 0.006) and lymph node metastasis (p = 0.048) but not cartilage invasion (p = 0.129). MVD was significantly higher in high-grade tumors (p = 0.003) but had no significant relationship between MVD, lymph node metastasis, and cartilage invasion (p = 0.815, p = 0.204). There was also no significant relationship between PTEN and VEGF expression (p = 0.161) and between PTEN and VEGF expression and the MVD (p = 0.120 and p = 0.175, respectively).ConclusionsIncreased VEGF expression may play an important role in the outcome of squamous cell carcinoma of the larynx. PTEN expression was not related to VEGF expression and clinicopathological features of squamous cell carcinoma of the larynx.

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Microvessel Density in Head and Neck Squamous Cell Carcinoma Primary Tumors and Its Correlation with Clinical Staging Parameters

Abstract: Our series demonstrates that there is a strong correlation between MVD in primary tumor hot spots and tumor T-stage, which implies that tumor angiogenesis may be a factor in tumor progression.

Cited by 30 publications

References 9 publications

Angiogenesis in Head and Neck Cancer

Angiogenesis in Head and Neck Cancer

The Role of Antiangiogenic Agents in the Treatment of Head and Neck Cancer

Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx

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