Microvessel quantification and its possible relation with liver metastasis in colorectal cancer

Tomisaki, Shinichi; Ohno, Shinji; Ichiyoshi, Yuji; Kuwano, Hiroyuki; Maehara, Yoshihiko; Sugimachi, Keizō

doi:10.1002/(sici)1097-0142(19960415)77:8<1722::aid-cncr46>3.0.co;2-z

Cited by 88 publications

(63 citation statements)

References 23 publications

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“…Because of these risk factors for peritoneal tumor spread, the intraoperative use of intraperitoneal chemotherapy [19] is required, with detection of free peritoneal tumor cells in peritoneal lavage fluid, using immunocytochemistry [20] and the reverse transcriptase-polymerase chain reaction [21]. Subsequent adjuvant therapy may be indicated for patients at high risk of further cancer spread or occult metastases, in patients with a tumor showing aneuploidy [22], p53 abnormality [23], or extensive neovascularization [24].…”

Section: Discussionmentioning

confidence: 99%

Prediction of recurrence after curative resection of gastric carcinoma invading the muscularis propria: a multivariate analysis

et al. 2000

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and early gastric cancer (EGC) as that confined to the mucosa or submucosa, regardless of the presence or absence of lymph node metastases. In Japan, the incidence of gastric cancer invading the muscularis propria (pm gastric cancer) accounts for about 10% of all patients with gastric cancer undergoing surgical resection [1,2]. The pm gastric cancer is usually treated by curative resection [3], and the 5-year survival rate for patients with pm gastric cancer was reported to be between 70% and 80%, a value between that for EGC and AGC [4,5]. Although pm gastric cancer belongs to the category of AGC, it is considered to be an intermediate stage between EGC and AGC [6], and the biological characteristics of pm gastric cancer are different from those of AGC [7].Recurrences of gastric cancer are likely to take a variety of forms and to be manifested in different organs, and the rate of recurrence increases in proportion to the degree of depth of invasion, even after curative resection for gastric cancer [8][9][10]. Although many prognostic factors for EGC and AGC have been identified [9,11], there are few reports concerning prognostic factors for pm gastric cancer, and the characteristics of recurrence are not well understood. For early detection and more effective treatment of recurrent disease, it is important to fully understand the relevant characteristics. We examined the clinicopathological characteristics of patients with pm gastric cancer in relation to recurrence. Patients and methods PatientsFrom 1965 to 1998, curative resection for 2437 Japanese patients with primary gastric cancer was done at the Second Department of Surgery at Kyushu University Hospital (Fukuoka, Japan). The present study is based Abstract Background. In Japan, the incidence of gastric cancer invading the muscularis propria is about 10% of all patients with gastric cancer undergoing surgical resection. Although many prognostic factors for early gastric cancer and advanced gastric cancer have been identified, there are few reports concerning prognostic factors for gastric cancer invading the muscularis propria, and the characteristics of recurrence are not well understood. Methods. We retrospectively analyzed data on 167 patients with gastric cancer that had invaded the muscularis propria. All patients had undergone curative resection. Results. Recurrences were evident in 37 patients (22.2%). Based on our univariate analysis, the recurrence was associated with lymph node metastases. Multivariate analysis showed that independent risk factors for recurrence were lymph node metastases and location of tumor in the upper or lower one-third of the stomach. With respect to the pattern of recurrence, 17 (46.0%) were secondary to hematogenous recurrence, 8 (21.6%) to peritoneal dissemination, and 6 (16.2%) to a local recurrence in the remnant stomach and in regional lymph nodes. Most deaths occurred during the second year after surgery, and approximately two-thirds of all patients (64.8%) died within 3 years after surgery. Conclusion. In patients ...

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Section: Discussionmentioning

confidence: 99%

Prediction of recurrence after curative resection of gastric carcinoma invading the muscularis propria: a multivariate analysis

et al. 2000

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“…9 -11 Subsequent studies by other investigators have shown the association of greater tumor aggressiveness with increasing MVD in other solid tumors. [23][24][25][26] Tumor vasculature is characterized by a tortuous architecture, 27 irregular blood flow, 28,29 and increased permeability relative to normal vessels. 30 There are also reports of a fenestrated endothelium and open interendothelial junctions in tumor vessels.…”

Section: Discussionmentioning

confidence: 99%

Intratumoral neovascularization and growth pattern in early gastric carcinoma

Tomoda

Maehara

Kakeji

et al. 1999

Cancer

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“…In the present investigation, a higher, but non-statistically significant microvessel density was found in patients presenting both synchronous and metachronous hematogenous metastases. The literature reports higher microvessel density in patients suffering from primary colorectal carcinoma and hematogenous metastasis (26,29,31) . However, angiogenesis quantification by itself cannot identify all the patients with hidden metastatic diseases nor even those who are likely to develop distant metastases, due to the heterogeneity of cell population and to the multiplicity of stages in the metastatic cascade which have to be accomplished by the tumor cells (16) .…”

Section: Microvessel Count and Patient Survivalmentioning

confidence: 99%

“…Despite the 22,8% difference, no statistical significance was found (P = 0.12), which may be put down to the sample size. The most of studies assessing angiogenesesis in colorectal carcinoma has shown a significant association between intense microvessel density (IMD) and survival reduction (5,7,10,11,12,15,20,22,23,24,25,26,29) (Table 4). VERMEULEN et al (31) carried on the first prospective study assessing angiogenesis in colorectal carcinoma, confirming the prognostic significance of microvessel counting previously demonstrated by retrospective studies.…”

Section: Microvessel Count and Patient Survivalmentioning

confidence: 99%

Angiogenesis in advanced colorectal adenocarcinoma with special reference to tumoral invasion

Tarta

Teixeira

Tanaka

et al. 2002

Arq. Gastroenterol.

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-Background -Angiogenesis is a crucial step in tumor growth and progression. Its quantification by microvessel counting has a prognostic value in several types of malignancies and recently has been appraised in gastrointestinal tumors. Aim -To assess the prognostisc significance of microvessel quantification in colorectal carcinomas, studying its association with hematogenous metastases, survival and clinicopathological variables such as size, histologic differentiation and depth of tumoral invasion. Patients/Methods -Forty eight patients with colorectal adenocarcinoma were included in this study. Histologic sections of invasion tumoral margin (4 µm) were analyzed and endothellined microvessels were immunostained with monoclonal mouse Von Willebrand Factor (anti-FVIII). The microvessel count was performed from the identification of the area with increased microvessel density -hot spots -and results of the mean in five of these fields. Results -The cut-off microvessel count was 14 microvessels/0,785 mm 2 , which divided the sample into hypovascular and hypervascular groups. While 2/8 (25%) tumors with muscularis propria invasion were classified as hypervascular, 11/15 (73%) tumors with serosa or perivisceral fat were classified as hypervascular. However, a non-significant statistical association was found between the angiogenesis quantification, hematogenous metastases, survival and clinicopathological variables such as size and histologic differentiation of the tumor. Conclusions -The findings of significantly increase of microvessel count in conformity with tumoral invasion depth supports the hypothesis that tumor progression might be related to angiogenesis. Although angiogenesis is an important step in the tumoral growth and during the metastatization process, other factors can be implicated.

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Microvessel quantification and its possible relation with liver metastasis in colorectal cancer

Cited by 88 publications

References 23 publications

Prediction of recurrence after curative resection of gastric carcinoma invading the muscularis propria: a multivariate analysis

Prediction of recurrence after curative resection of gastric carcinoma invading the muscularis propria: a multivariate analysis

Intratumoral neovascularization and growth pattern in early gastric carcinoma

Angiogenesis in advanced colorectal adenocarcinoma with special reference to tumoral invasion

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