Microwave Ablation as a Treatment for Spinal Metastatic Tumors: A Systematic Review

Sagoo, Navraj S.; Haider, Ali S; Rowe, Scott E.; Haider, Maryam; Sharma, Rohini; Neeley, Om James; Dahdaleh, Nader S.; Adogwa, Owoicho; Bagley, Carlos A.; Ahmadieh, Tarek Y. El; Aoun, Salah G.

doi:10.1016/j.wneu.2020.12.162

Cited by 25 publications

(27 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 Many ablation adjuvant therapies, such as radiofrequency ablation, MWA ablation, and cryoablation, have been used in open decompression surgery to relieve pain or improve tumor control. 5,21,22 Pain Relief after Ablation Microwaves are more effective than radiofrequency ablation because of the poor heat conduction of bone in the latter. 23 In addition, MWA has the advantages of larger ablation zones and shorter operational times.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of studies have focused on the application of MWA to treat spinal metastases. 5 Percutaneous MWA for metastases has been reported to be effective in achieving analgesia in the short term. 12,27,28 Khan et al 27 reported a dramatic reduction of the pain score after percutaneous MWA and cementoplasty in 84 thoracolumbar sites of painful spinal metastases and myeloma.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of combined microwave ablation and open surgery for the treatment of lung cancer‐derived thoracolumbar metastases

Zeng

et al. 2022

Orthopaedic Surgery

View full text Add to dashboard Cite

Objective: To investigate the clinical effects of microwave ablation (MWA) in addition to open surgery for the treatment of lung cancer-derived thoracolumbar metastases.Methods: This was a single-institution, retrospective, cohort study. From January 2019 to December 2020, a total of 47 patients with lung cancer-derived thoracolumbar metastases underwent posterior spinal canal decompression and fixation surgery in our hospital. Two independent surgical teams treated these patients. One group underwent open surgery combined with MWA therapy, while the other had open surgery only (control). The pre-and post-operative visual analog scale (VAS) scores and the overall survival (OS) were compared between the MWA and control groups. The Frankel Grade classification was applied for the evaluation of the post-surgical spinal cord function. Improvement was defined as an increase of at least one rank from the pre-operative scores. Each patient was evaluated pre-and postoperatively at 48 h, 1 month, and 3-month intervals. Data on surgical-related complications were recorded.Results: Thirty men and 17 women were included, with an average age of 57.9 AE 11.4 years (range, 26-81 years).Twenty-eight patients underwent MWA and were in the MWA group, and 19 patients were included in the control group. Post-operatively all patients were followed up regularly; the median follow-up time was 12 months (range, 3-24 months), and their median OS was 14 months. Patients in the MWA group had a lower VAS score than those in the control group at the 48-h (1.75 AE 1.01 vs 2.47 AE 0.96, P = 0.01) and 1-month (1.79 AE 0.92 vs 2.53 AE 1.35, P = 0.048) check-ups. At the 3-month evaluation, the VAS score differences between the two groups were not significant (P = 0.133). After surgery, spinal cord function improvement was not significantly different between the MWA and control groups (P = 0.515). MWA therapy combined with open surgery was not associated with increased OS compared with the control group (P = 0.492). Conclusion:MWA can be an effective and safe pain-relief method but may not extend the OS of patients with lung cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of combined microwave ablation and open surgery for the treatment of lung cancer‐derived thoracolumbar metastases

Zeng

et al. 2022

Orthopaedic Surgery

View full text Add to dashboard Cite

show abstract

Section: Microwave Ablationmentioning

confidence: 99%

“…Although to date there are still few studies available, literature reports promising results regarding the palliative role of MWA for bone metastases and its efficacy in LTC, proving that MWA is a feasible and effective treatment for pain relief and quality of life improvement [ 107 , 108 , 109 , 110 , 111 , 112 , 113 ]. In a systematic literature review, Sagoo et al [ 108 ] evaluated the use of MWA in the treatment of painful spinal metastases in eight studies, demonstrating MWA to be effective in achieving pain palliation for up to 6 months and local tumor control (success rate of 80-100%). Similarly, Cazzato et al [ 109 ] conducted a systematic review regarding MWA safety and clinical efficacy and according to the seven studies analyzed, MWA is effective in achieving short-(1 month) and mid-term (4–6 months) pain relief after treating painful bone tumors, including skeletal metastases.…”

Section: Microwave Ablationmentioning

confidence: 99%

Minimally Invasive Interventional Procedures for Metastatic Bone Disease: A Comprehensive Review

Papalexis¹,

Parmeggiani²,

Peta³

et al. 2022

Current Oncology

View full text Add to dashboard Cite

Metastases are the main type of malignancy involving bone, which is the third most frequent site of metastatic carcinoma, after lung and liver. Skeletal-related events such as intractable pain, spinal cord compression, and pathologic fractures pose a serious burden on patients’ quality of life. For this reason, mini-invasive treatments for the management of bone metastases were developed with the goal of pain relief and functional status improvement. These techniques include embolization, thermal ablation, electrochemotherapy, cementoplasty, and MRI-guided high-intensity focused ultrasound. In order to achieve durable pain palliation and disease control, mini-invasive procedures are combined with chemotherapy, radiation therapy, surgery, or analgesics. The purpose of this review is to summarize the recently published literature regarding interventional radiology procedures in the treatment of cancer patients with bone metastases, focusing on the efficacy, complications, local disease control and recurrence rate.

show abstract

“…This approach in 31 tumors throughout the spine resulted in significant decreases in numeric rating scores at 1 week, 1 month, and 3 months and persistent local tumor control in 30 cases after 10 months. A recent systematic review reported that microwave ablation technology might provide a possible advantage over other methods with larger ablation zones, shorter procedure times and potentially more effective ablative lesions with higher bony tissue impedance [79]. Adverse events in reported studies are rare, with the most common related to transient neuropathy or nerve injuries [10,13,14,16].…”

Section: Spinal Tumor Ablationmentioning

confidence: 99%

Interventional Procedures for Vertebral Diseases: Spinal Tumor Ablation, Vertebral Augmentation, and Basivertebral Nerve Ablation—A Scoping Review

et al. 2021

View full text Add to dashboard Cite

Low back pain is consistently documented as the most expensive and leading cause of disability. The majority of cases have non-specific etiologies. However, a subset of vertebral diseases has well-documented pain generators, including vertebral body tumors, vertebral body fractures, and vertebral endplate injury. Over the past two decades, specific interventional procedures targeting these anatomical pain generators have been widely studied, including spinal tumor ablation, vertebral augmentation, and basivertebral nerve ablation. This scoping review summarizes safety and clinical efficacy and discusses the impact on healthcare utilization of these interventions. Vertebral-related diseases remain a top concern with regard to prevalence and amount of health care spending worldwide. Our study shows that for a subset of disorders related to the vertebrae, spinal tumor ablation, vertebral augmentation, and basivertebral nerve ablation are safe and clinically effective interventions to decrease pain, improve function and quality of life, and potentially reduce mortality, improve survival, and overall offer cost-saving opportunities.

show abstract

Microwave Ablation as a Treatment for Spinal Metastatic Tumors: A Systematic Review

Cited by 25 publications

References 19 publications

The effects of combined microwave ablation and open surgery for the treatment of lung cancer‐derived thoracolumbar metastases

The effects of combined microwave ablation and open surgery for the treatment of lung cancer‐derived thoracolumbar metastases

Minimally Invasive Interventional Procedures for Metastatic Bone Disease: A Comprehensive Review

Interventional Procedures for Vertebral Diseases: Spinal Tumor Ablation, Vertebral Augmentation, and Basivertebral Nerve Ablation—A Scoping Review

Contact Info

Product

Resources

About