Microwave ablation compared with radiofrequency ablation for the treatment of liver cancer: a systematic review and meta-analysis

Spiliotis, Antonios E.; Gäbelein, Gereon; Holländer, Sebastian; Scherber, Philipp-Robert; Glanemann, Matthias; Patel, Bijendra

doi:10.2478/raon-2021-0030

Cited by 28 publications

(24 citation statements)

References 42 publications

(172 reference statements)

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“…RFA, as one of the major approaches for clinical non-surgical treatment of liver cancer, has the advantages of less trauma and fewer complications [ 20 ]. However, a number of studies have shown that liver cancer patients had a higher incidence of recurrence after RFA [ 21 , 22 ], so it is of great significance to predict the curative effect and prognosis of patients after RFA early.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of MRI with Serum Lectin-Reactive Alpha-Fetoprotein for Liver Cancer Recurrence after Percutaneous Radiofrequency Ablation

Zhang

Yao

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the predictive value of magnetic resonance imaging (MRI) with serum lectin-reactive alpha-fetoprotein (AFP-L3) for liver cancer recurrence after percutaneous radiofrequency ablation (RFA). Methods. This study included 94 liver cancer patients admitted for RFA treatment and 82 healthy subjects. MRI was performed to record the apparent diffusion coefficient (ADC). The serum concentrations of AFP-L3 were quantified in all participants. The correlation of the AFP-L3 serum level and ADC value with clinical efficacy following RFA was analyzed. Moreover, the prognostic factors affecting liver cancer recurrence were analyzed, as well as the predictive effect of the ADC value and AFP-L3 on liver cancer recurrence. Results. The serum AFP-L3 level was higher in liver cancer patients than the healthy controls with a lower ADC value. Besides, the patients with tumor residuals had lower ADC values and higher serum AFP-L3 levels than those with complete ablated tumor. The combined detection of the ADC value and serum AFP-L3 level had a sensitivity of 87.50% and a specificity of 87.18% for diagnosing complete ablation after RFA treatment. The number of tumor nodules, tumor diameter, AFP, AFP-L3, and the presence of liver cirrhosis are all independent risk factors for liver cancer recurrence within one year. Meanwhile, the combined detection of the ADC value and serum AFP-L3 level had a good predictive effect on liver cancer recurrence with the sensitivity of 92.86% and a specificity of 69.62%. Conclusion. The ADC values combined with serum AFP-L3 detection had good predictive effects on complete ablation and recurrence of liver cancer after RFA treatment.

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Section: Discussionmentioning

confidence: 99%

Predictive Value of MRI with Serum Lectin-Reactive Alpha-Fetoprotein for Liver Cancer Recurrence after Percutaneous Radiofrequency Ablation

Zhang

Yao

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…HCC patients after RFA treatment show low recurrence and mortality rate, which achieves similar curative effect as surgery to some extent ( 33 – 36 ). Previous studies also supported low recurrence rate and only mild adverse reactions, including fever, neutrophils, local pain and minor thermal damage in peripheral organs ( 37 – 39 ).…”

Section: The Principle Of the Ablation Techniquesmentioning

confidence: 59%

Clinical application status and prospect of the combined anti-tumor strategy of ablation and immunotherapy

Li¹,

Zhu³

et al. 2022

Front. Immunol.

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Image-guided tumor ablation eliminates tumor cells by physical or chemical stimulation, which shows less invasive and more precise in local tumor treatment. Tumor ablation provides a treatment option for medically inoperable patients. Currently, clinical ablation techniques are widely used in clinical practice, including cryoablation, radiofrequency ablation (RFA), and microwave ablation (MWA). Previous clinical studies indicated that ablation treatment activated immune responses besides killing tumor cells directly, such as short-term anti-tumor response, immunosuppression reduction, specific and non-specific immune enhancement, and the reduction or disappearance of distant tumor foci. However, tumor ablation transiently induced immune response. The combination of ablation and immunotherapy is expected to achieve better therapeutic results in clinical application. In this paper, we provided a summary of the principle, clinical application status, and immune effects of tumor ablation technologies for tumor treatment. Moreover, we discussed the clinical application of different combination of ablation techniques with immunotherapy and proposed possible solutions for the challenges encountered by combined therapy. It is hoped to provide a new idea and reference for the clinical application of combinate treatment of tumor ablation and immunotherapy.

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“…Although it is currently the preferred treatment for FNH, some scholars ( Virgilio and Cavallini, 2018 ) believe that surgical resection-related complications and mortality are serious and unacceptable for the treatment of benign diseases. The common complications of thermal ablation for liver cancer mainly include subcapsular hematoma, abdominal skin burn and pleural effusion ( Spiliotis et al, 2021 ). These complications may also occur during FNH treatment.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Percutaneous Thermal Ablation of Hepatic Focal Nodular Hyperplasia——A Multicenter Retrospective Study

Xuan

Chang²,

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Background and Aim: To evaluate the clinical effect of ultrasound (US)-guided percutaneous thermal ablation of hepatic focal nodular hyperplasia (FNH).Methods: A retrospective analysis of the clinical data of patients undergoing US-guided percutaneous thermal ablation of FNH from November 2008 to August 2021 at five medical centers in China was conducted.Results: A total of 53 patients were included (26 males and 27 females). The mean age was 35.1 ± 10.8 years. Sixty-five lesions (46 solitary cases and 7 cases with multiple lesions) were included, 70.8% (46/65) of which were located in the right liver lobe. The mean tumor length was 2.9 ± 1.5 cm. All patients successfully completed the ablation treatment. Immediate postoperative imaging showed that the primary technical success rate was 94.3% (50/53). Two patients underwent ablation 3 and 6 months after the primary ablation, and the secondary technical success rate was 100% (2/2). The incidence of complications was 3.8% (2/53). Imaging follow-up was conducted regularly after ablation, and no residual lesion enlargement or tumor recurrence was observed during the follow-up period. The technique efficacy rate was 98.1% (52/53).Conclusion: US-guided percutaneous thermal ablation is a safe and effective treatment for FNH of the liver.

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Microwave ablation compared with radiofrequency ablation for the treatment of liver cancer: a systematic review and meta-analysis

Cited by 28 publications

References 42 publications

Predictive Value of MRI with Serum Lectin-Reactive Alpha-Fetoprotein for Liver Cancer Recurrence after Percutaneous Radiofrequency Ablation

Predictive Value of MRI with Serum Lectin-Reactive Alpha-Fetoprotein for Liver Cancer Recurrence after Percutaneous Radiofrequency Ablation

Clinical application status and prospect of the combined anti-tumor strategy of ablation and immunotherapy

Ultrasound-Guided Percutaneous Thermal Ablation of Hepatic Focal Nodular Hyperplasia——A Multicenter Retrospective Study

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