Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer

Lei, Yu; Xie, Hairong; Wang, Linping; Cheng, Min; Liu, Jie; Xu, Jing; Wei, Zhigang; Ye, Xin; Xie, Qi; Liang, Jing

doi:10.3389/fonc.2023.1174713

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Huang et al found that MWA alone failed to produce a significant abscopal effect, but the combination of MWA and immunotherapy resulted in the inhibition of distant tumor growth and reduced recurrence [27]. On the other hand, Yu reported that MWA not only suppressed tumor growth in the primary tumors but also stimulated an abscopal effect in CT26-bearing mice via the improvement of systemic and intratumoral antitumor immunity [42]. These studies implied that although MWA, like other ablative therapies, has an increase in interleukin-1 and heat shock proteins during cancer cell death via thermal injury, MWA is less inducible compared to radiofrequency ablation and cryoablation [35,43].…”

Section: Discussionmentioning

confidence: 99%

Inducing the Abscopal Effect in Liver Cancer Treatment: The Impact of Microwave Ablation Power Levels and PD-1 Antibody Therapy

Liao,

Zhang,

Huang

et al. 2023

Pharmaceuticals

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Microwave ablation (MWA) is an effective treatment for liver cancer (LC), but its impact on distant tumors remains to be fully elucidated. This study investigated the abscopal effects triggered by MWA treatment of LC, at different power levels and with or without combined immune checkpoint inhibition (ICI). We established a mouse model with bilateral subcutaneous LC and applied MWA of varied power levels to ablate the right-sided tumor, with or without immunotherapy. Left-sided tumor growth was monitored to assess the abscopal effect. Immune cell infiltration and distant tumor neovascularization were quantified via immunohistochemistry, revealing insights into the tumor microenvironment and neovascularization status. Th1- and Th2-type cytokine concentrations in peripheral blood were measured using ELISA to evaluate systemic immunological changes. It was found that MWA alone, especially at lower power, promoted distant tumor growth. On the contrary, combining high-power MWA with anti-programmed death (PD)-1 therapy promoted CD8+ T-cell infiltration, reduced regulatory T-cell infiltration, upregulated a Th1-type cytokine (TNF-α) in peripheral blood, and inhibited distant tumor growth. In summary, combining high-power MWA with ICI significantly enhances systemic antitumor immune responses and activates the abscopal effect, offering a facile and robust strategy for improving treatment outcomes.

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Section: Discussionmentioning

confidence: 99%

Inducing the Abscopal Effect in Liver Cancer Treatment: The Impact of Microwave Ablation Power Levels and PD-1 Antibody Therapy

Liao,

Zhang,

Huang

et al. 2023

Pharmaceuticals

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“…In addition, recent studies have highlighted the potential of thermal ablation to induce systemic anti-tumor immunity, exhibiting the abscopal effect in which the ablation of local tumors leads to the regression of distant untreated tumor sites (32)(33)(34)(35). Cite a case, a 69-year-old patient with metastatic lung squamous cell carcinoma underwent MWA of a lesion in the right lower lung after developing immunotherapy resistance.…”

Section: Impact Of Thermal Ablation On Immunitymentioning

confidence: 99%

Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation

Sang,

2023

Front. Immunol.

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Thermal ablation is a promising alternative treatment for lung cancer. It disintegrates cancer cells and releases antigens, followed by the remodeling of local tumor immune microenvironment and the activation of anti-tumor immune responses, enhancing the overall effectiveness of the treatment. Biomarkers can offer insights into the patient’s immune response and outcomes, such as local tumor control, recurrence, overall survival, and progression-free survival. Identifying and validating such biomarkers can significantly impact clinical decision-making, leading to personalized treatment strategies and improved patient outcomes. This review provides a comprehensive overview of the current state of research on potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation, including their potential role in lung cancer management, and the challenges and future directions.

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“…Xu et al ( 15 ) reported spontaneous regression of distant tumor lesions after MWA in patients with lung metastasis of endometrial carcinoma. To the best of our knowledge, however, few cases of MWA-induced abscopal effects have been reported ( 16 ), and the specific mechanisms underlying the abscopal effects remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Microwave ablation enhances the systemic immune response in patients with lung cancer

Ma,

Lin,

et al. 2024

Oncol Lett

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Microwave ablation (MWA) is a key alternative therapy to conventional surgery for the treatment of lung cancer. In addition to eliminating local tumors, MWA may promote antitumor immunological responses, such as abscopal effects in distant lesions. However, the intensity of MWA is limited and the underlying mechanisms are not well-defined. The present study assessed the impact of MWA on immune cell subsets and cytokines in patients with lung cancer. A total of 45 patients with lung cancer who underwent percutaneous lung tumor MWA were enrolled. Peripheral blood samples were collected before and 24 h after MWA and changes in immune cell subsets [lymphocytes, CD3 + , CD4 + and CD8 + T cells, B cells and natural killer (NK) cells] and serum cytokine levels (IL-1β, IL-2, IL-4-6, IL-8, IL-10, IL-12p70, IL-17A and F, IL-22, TNF-α, TNF-β and IFN-γ) were assessed by flow cytometry and ELISA. The number of total lymphocytes, CD4 + T and NK cells in the peripheral blood significantly decreased 24 h after MWA, while number of CD8+ T cells remained stable, leading to a higher proportion of CD8 + T cells. In addition, the serum levels of IL-2, IL-1β, IL-6, IL-12p70, IL-22, TNF-α and IFN-γ were significantly increased 24 h after MWA, indicating a T helper 1 type immune response. The immune response in patients with advanced stage disease was comparable with patients in the early stage group; however, the number of total lymphocytes and CD3 + T cells significantly decreased and the ratio of CD4/CD8 and IL-2 levels significantly increased. The early immune response after MWA may contribute to systemic antitumor immunity in patients with both early and advanced disease. Thus, MWA may exhibit potential as a local therapy and trigger abscopal effects in distant lesions in patients with lung cancer.

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Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer

Cited by 5 publications

References 42 publications

Inducing the Abscopal Effect in Liver Cancer Treatment: The Impact of Microwave Ablation Power Levels and PD-1 Antibody Therapy

Inducing the Abscopal Effect in Liver Cancer Treatment: The Impact of Microwave Ablation Power Levels and PD-1 Antibody Therapy

Potential biomarkers for predicting immune response and outcomes in lung cancer patients undergoing thermal ablation

Microwave ablation enhances the systemic immune response in patients with lung cancer

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