Microwave Ablation: Results with a 2.45-GHz Applicator in ex Vivo Bovine and in Vivo Porcine Liver

Hines-Peralta, Andrew; Pirani, Nadeer; Clegg, Peter; Cronin, N. J.; Ryan, Thomas P.; Liu, Zhenjun; Goldberg, S. Nahum

doi:10.1148/radiol.2383050262

Cited by 161 publications

(155 citation statements)

References 39 publications

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“…15,16 However, there is considerable technical difficulty in probe repositioning during overlapping ablations, especially under ultrasound guidance, owing to gas bubble formations, ultimately resulting in incomplete ablations. [17][18][19] Recently, multiple-electrode RFA approaches, including the switching monopolar (SM) mode, bipolar mode and multipolar mode, have been attempted with each demonstrating efficiency in creating a larger ablation zone in liver tissue than in the standard monopolar RF technique. 2,[20][21][22][23][24][25][26] Theoretically, RFA in switching bipolar (SB) mode using multiple electrodes should further improve the thermal and electronic efficiency of RFA devices compared to conventional monopolar modes.…”

mentioning

confidence: 99%

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Yoon

Lee²,

Woo

et al. 2015

BJR

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Objective: To evaluate whether switching bipolar radiofrequency ablation (SB-RFA) using three internally cooled wet (ICW) electrodes can induce coagulations .5 cm in porcine livers with better efficiency than consecutive monopolar (CM) or switching monopolar (SM) modes. The mean D min of coagulations was significantly larger in Group C than in Groups A and B (5.1 6 0.9, 3.9 6 1.2 and 4.4 6 1.0 cm, respectively, p 5 0.002) at a lower delivered RF energy level (76.8 6 14.3, 120.9 6 24.5 and 114.2 6 18.3 kJ, respectively, p , 0.001). Conclusion: SB-RFA using three ICW electrodes can create coagulations .5 cm in diameter with better efficiency than do SM-or CM-RFA. Advances in knowledge: SB-RFA can create large, regular ablation zones with better time-energy efficiency than do CM-or SM-RFA.

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mentioning

confidence: 99%

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Yoon

Lee²,

Woo

et al. 2015

BJR

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“…[4][5][6][7][8] Microwave ablation method is much safer and easily manageable 9 and can, in principle, offer material-specific responsiveness, where tissues with high water content such as cancer are preferentially heated and damaged. 10,11 This characteristic of microwaves makes microwave ablation well suited for local treatment of early stage of breast cancer. So far, the frequencies used in the existing microwave ablation systems have been limited to the low-frequency spectrum such as 915 MHz or 2.4 GHz.…”

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confidence: 99%

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Yoon

Cho

Kim

et al. 2011

Intl Journal of Cancer

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To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1-3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor with minimized invasiveness and collateral damages.Breast cancer is a major threat to women's health psychologically as well as physically. 1 Despite the high potential of fatality, most women show reluctance for large-scale breast removal due to cosmetic concerns, which brings about the need for local surgical control. For this reason, minimally invasive techniques to achieve better local surgical control have collected extensive attention as a possible first-line treatment in lieu of conservative breast surgery procedures such as lumpectomy. 2,3 Among several alternative methods, microwave ablation entails many benefits in comparison with the others such as laser ablation, cryoablation and ethanol ablation. [4][5][6][7][8] Microwave ablation method is much safer and easily manageable 9 and can, in principle, offer material-specific responsiveness, where tissues with high water content such as cancer are preferentially heated and damaged. 10,11 This characteristic of microwaves makes microwave ablation well suited for local treatment of early stage of breast cancer. So far, the frequencies used in the existing microwave ablation systems have been limited to the low-frequency spectrum such as 915 MHz or 2.4 GHz. Because of the inherent low radiation efficiency, very high microwave input power of several tens of Watts is required at these frequencies, thus greatly increasing the cost and size of the equipment. 12 Moreover, because of the self-heating of the applicator by the excessive microwave power, additional means for cooling the applicator are required to avoid the damage of healthy tissues near the passage of the applicator. 13 Besides, the conventional low-frequency spectrum ablation has poor material selectivity when compared to the alternative high-frequency spectrum proposed in our work.To overcome the limitations of the existing microwave ablation methods, we have investigated the properties of microwaves up to 30 GHz wit...

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“…The high temperature produced by the electrodes inserted into the tumor tissue results in the rapid coagulation and necrosis of the tumor tissue, thus achieving the goal of destroying the tumor. The area of PMCT is related to the diameter and number of the microwave electrode, the output power of the machine, coagulation time, and local blood circulation [7,[10][11][12][13] . Increases in the diameter of the electrodes, the output power, and the coagulation time may enlarge the treatment areas of PMCT.…”

Section: Discussionmentioning

confidence: 99%

Combined therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation for small hepatocellular carcinoma

Weizhu¹,

Jiang²,

Huang³

et al. 2009

WJG

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AIM:To assess the efficacy of combined transcatheter arterial chemoembolization (TACE) and percutaneous microwave coagulation therapy (PMCT) for small hepatocellular carcinoma (HCC). METHODS:Thirty-five patients with a total of 41 HCC nodules (≤ 3 cm in diameter) were treated with TACE followed by computed tomograghy (CT)-guided percutaneous microwave coagulation therapy (PMCT) within 1-3 wk. RESULTS:By biopsies and enhanced CT scans, complete necrosis of the tumor and 3-5 mm of the surrounding non-cancerous area were observed in 34 foci. In seven foci, incomplete necrosis of the surrounding parenchyma was observed. Serum alphafetoprotein (AFP) levels returned to normal 10 d after treatment in 25 patients who originally had high serum AFP levels. The follow-up period was 6-31 mo, and all patients remained alive. One patient had a recurrence in the subsegments of the liver, and another patient had a recurrence near the original lesion. CONCLUSION:Combined therapy with TACE and PMCT is a safe and effective treatment without severe complications for small HCC.

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Microwave Ablation: Results with a 2.45-GHz Applicator in ex Vivo Bovine and in Vivo Porcine Liver

Cited by 161 publications

References 39 publications

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

Switching bipolar hepatic radiofrequency ablation using internally cooled wet electrodes: comparison with consecutive monopolar and switching monopolar modes

High‐frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage

Combined therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation for small hepatocellular carcinoma

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