Microwave‐Accelerated Cross‐Dehydrogenative Coupling of Quinoxalin‐2(1H)‐ones with Alkanes under Transition‐Metal‐Free Conditions

Abstract

With simple alkanes as the alkyl radical precursors under microwave irradiation, a convenient and efficient cross‐dehydrogenative alkylation reaction of quinoxalin‐2(1H)‐ones and other N‐heteroarenes has been achieved. The protocol demonstrates a broad substrate scope, good functional group tolerance, high atom economy and high efficiency, providing a wide range of valuable, structurally diverse C3 alkylated quinoxalin‐2(1H)‐ones and other alkylated N‐heteroarenes in good‐to‐excellent yields.

Pursuing high efficiency in photocatalytic oxidative couplings of heteroarenes and aliphatic C–H bonds

“…19 Often, thermolysis of these organic oxidants at high temperatures (100–140 °C) was employed to produce alkoxy or benzoyl radical from di- t -butyl peroxide or benzoyl peroxide for oxidative couplings. 20 One of these conditions employed Sc(OTf) 3 for in situ activation of azacycles, for instance (see Fig. 2d).…”