Microwave-assisted Cu(<scp>i</scp>)-catalyzed one-pot tandem synthesis of pyridoimidazole-fused quinolines as new antimycobacterial agents: DFT and ESI-HRMS study

Pawar, Gaurav; Ghouse, Shaik Mahammad; Joshi, Swanand Vinayak; Ahmad, Mohammad Naiyaz; Dasgupta, Arunava; Yaddanapudi, Venkata Madhavi; Chopra, Sidharth; Nanduri, Srinivas

doi:10.1039/d2nj06165a

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2024

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Cited by 3 publications

References 38 publications

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Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols

Gómez‐Gil,

Cases,

Hernández‐Ruiz

et al. 2024

Eur J Org Chem

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We report the efficient, sustainable one‐pot synthesis of a wide variety of N‐polyheterocycles, such as imidazo‐quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction‐imine formation‐intramolecular cyclization‐oxidation sequence. It is worth highlighting that the recycling and incorporation of the waste carbonyl byproduct, generated in the reduction step, into the final compound is realized. In addition, the overall efficiency and atom economy of the process are further improved owing to the participation of one reaction intermediate as reductant that allows lowering the amount of external reducing agent employed.

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Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols

Gómez‐Gil,

Cases,

Hernández‐Ruiz

et al. 2024

Eur J Org Chem

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show abstract

Environmental-benign pathways for the synthesis of medicinally relevant heterocycles

Garg,

Bhalla

2024

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

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Exploration of 1,3,5-trisubstituted pyrazoline derivatives as human carbonic anhydrase inhibitors: Synthesis, biological evaluation and in silico studies

Srikanth,

Shanthi,

Paoletti

et al. 2024

International Journal of Biological Macromolecules

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Microwave-assisted Cu(i)-catalyzed one-pot tandem synthesis of pyridoimidazole-fused quinolines as new antimycobacterial agents: DFT and ESI-HRMS study

Abstract: In this study, a new microwave irradiation protocol was developed for synthesizing pyrido [2',1':2,3] imidazo[4,5-c] quinolines using 2-(2-bromophenyl) imidazo[1,2-a] pyridine and various benzaldehydes. This protocol also employed benzyl alcohols and...

Cited by 3 publications

References 38 publications

Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols

Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols

Environmental-benign pathways for the synthesis of medicinally relevant heterocycles

Exploration of 1,3,5-trisubstituted pyrazoline derivatives as human carbonic anhydrase inhibitors: Synthesis, biological evaluation and in silico studies

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