Microwave-assisted DABCO-promoted regioselective [3 + 3] tandem cyclization: synthesis of pyrrolo[3,4-b]pyridine-4-ones from trifluoromethyl-alkynyl esters and α-aminomaleimide

Abstract

A microwave-assisted DABCO-promoted strategy for the regioselective synthesis of pyrrolo[3,4-b]pyridine-4-ones derivatives has been developed from the [3 + 3] annulation of α-aminomaleimide with substituted ethyl 2-butynoate. The characteristic features of...

One-pot FeCl3-catalyzed sustainable synthesis of pyrimidines using ammonium iodide, aldehydes and alkyl lactate as raw materials

“…In our investigation of organic reactions using ethyl lactate (EL) as a solvent, we observed that the classical conversion of EL involves dehydrogenating its alcohol fragment to ethyl pyruvate. 18 Building on this transformation and our group's expertise in synthesizing nitrogen-containing heterocyclic compounds from imine intermediates, 19 we developed a novel approach for directly synthesizing pyrimidines from EL. This sustainable method involves capturing ethyl pyruvate generated in situ by EL through iron( iii )-catalyzed formation of quaternary ammonium salts from inorganic NH 4 I and benzaldehyde.…”