Microwave-Assisted Extraction of Methyl β-Cyclodextrin-Complexed Curcumin from Turmeric Rhizome Oleoresin

Abstract

In this work, methyl β-cyclodextrin (Mβ-CD) was used to increase the solubility of turmeric rhizome oleoresin (TRO) in aqueous solution by forming inclusion complexes, and the technique was combined with microwave-assisted extraction (MAE) to extract the curcuminoids from Curcuma domestica Val. Optimized conditions for the MAE were microwave power of 700 W, extraction particle size of 0.30-0.60 mm, extraction time of 3 min, solvent volume of 10 mL, 2 g of sample, and extraction temperature of 60°C. High-performance liquid chromatography was used for the determination of the curcuminoids. Phase solubility study was conducted to investigate the association of Mβ-CD with TRO using curcumin, the major curcuminoid, as a marker compound to represent turmeric oleoresin. The curcumin recovery was increased due to its complexation with Mβ-CD. Linear host-guest correlation with slope of <1 indicated a stoichiometry of 1:1 Mβ-CD-complex, and with this assumption, the stability constant, K C , was calculated as 515.19 M −1 .Meanwhile, the molar ratio needed for inclusion complexation between TRO/Mβ-CD was 1:2. Attenuated total reflectance Fourier transform infrared spectroscopy results revealed that the MAE application for the co-precipitation, physical, and kneading methods can all be used for complexation.

Impact of Cell Disintegration Techniques on Curcumin Recovery

“…MAE has long been known as a rapid and economic-assisted extraction method [119] which requires less energy due to directly heating inside the product [24]. Unlike conventional heating techniques, MAE easily breaks the hydrogen bonds in the materials by electromagnetic effect, resulting in increased solvent penetration and diffusion of soluble compounds into the solvent [107,108]. According to [120], MAE has been proved a promising assisted extraction technology, which could minimize the thermal degradation of the bioactive compound due to rapid heating mechanism and create fast mass transfer [24].…”

Development of an Aqueous Polyethylene Glycol-Based Extraction and Recovery Method for Almond (Prunus armeniaca L.) Protein

“…Unlike classical heating, microwaves heat the entire sample simultaneously and MAE offers advantages like improved extraction efficiencies, reduced extraction time, and low solvent consumption (Papadakis et al 2014). Therefore, MAE has been widely applied to the extraction of various ingredients from different matrices (Liu et al 2012;Hadi et al 2015;Ramezani et al 2015). Over recent years, response surface methodology (RSM) has been extensively used to develop, improve, and optimize extractions of the chemical substances (Liu et al 2013;Habibi et al 2013;Lee et al 2014;Sarfarazi et al 2015;Barizao et al 2015).…”