Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase

Yuan, Yuan; Zhang, Jian; Fan, Jiajun; Clark, James H.; Shen, Peili; Li, Yiqiang; Zhang, Chengsheng

doi:10.1016/j.foodres.2018.07.021

Cited by 180 publications

(108 citation statements)

References 38 publications

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“…Microwave radiation can also stimulate cuticular layer destruction which was observed as very rough algae surface with many cavities after high pressure (120 psi) MAE application [56]. MAE has been successfully used for isolation of various bioactive compound from seaweeds [57][58][59][60] as well as polysaccharides from other plants [61][62][63]. Application of MAE for brown APS extraction is summarized in Table 2 along with its effect on chemical structure and bioactivities of target polysaccharides.…”

Section: Advanced Extraction Techniquesmentioning

confidence: 99%

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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Over the years, brown algae bioactive polysaccharides laminarin, alginate and fucoidan have been isolated and used in functional foods, cosmeceutical and pharmaceutical industries. The extraction process of these polysaccharides includes several complex and time-consuming steps and the correct adjustment of extraction parameters (e.g., time, temperature, power, pressure, solvent and sample to solvent ratio) greatly influences the yield, physical, chemical and biochemical properties as well as their biological activities. This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process. The influence of these extraction techniques and their individual parameters on yield, chemical structure and biological activities from the most current literature is discussed, along with their potential for commercial applications as bioactive compounds and drug delivery systems.(APS) is determined by algae species however it is also influenced by other factors causing inter-species variation, e.g., growth location and harvesting season [8]. Vast structural variation between the APS therefore presents a challenge in terms of pre-treatments application, extraction techniques and optimization, characterization of isolated fractions and determination of their biological properties.Chemical structure and yield of APS isolated from marine macroalgae by conventional extraction (CE) techniques can be affected by various experimental conditions (pH, time, temperature, pressure, particle size, solvent, sample to solvent ratio, agitation speed etc.). In addition, different advanced techniques such as microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), pressurized liquid extraction (PLE), enzyme-assisted extractions (EAE) are assessed and applied for APS extraction [9][10][11].In general, the chemical structure of polysaccharides determines its physical, chemical and biochemical properties as well as its biological activities [12]. Several studies have reported that their biological activity is strongly associated with their chemical structure [9]. Due to very complex mechanisms that are affected by many factors, the correlation between polysaccharide structure and biological activity is still not sufficiently clarified.In order to improve isolation of APS, pre-treatments are usually applied to the algal biomass prior to the extraction process with the two aims: (i) to prevent co-extraction of interfering bioactive compounds with similar solubility; and (ii) to disrupt cell walls and improve mass transfer of APS into extraction solvent. The first type of pre-treatments is therefore used to remove compounds which are highly bound to the APS such as proteins, phenols and lipids, as well as mannitol and chlorophyll [13]. For that purpose, the application of various pr...

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Section: Advanced Extraction Techniquesmentioning

confidence: 99%

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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“…Table 4 summarizes the studies concerning the MAE extraction of phenolic compounds from macroalgae. Ethanol:water mixtures have been the most commonly used in MAE of phenolic compounds from macroalgae [108,109], although few authors have applied acetone:water mixtures [54], methanol:water [110], or just water [111]. Pérez et al studied and optimized the MAE of phenolic compounds from Sargassum muticum wet samples in two stages, with a solvent-free extraction followed by a water extraction, adding only the moisture content [112].…”

Section: Microwave-assisted Extractionmentioning

confidence: 99%

“…Again, most studies concerning the MAE of phenolic compounds from macroalgae have not characterized the extracts obtained, revealing a major weakness in these works. However, a recent study showed that this technique is able to extract different families of phenolic compounds, including phenolic acids, flavonoids, and phlorotannins from different brown macroalgae species [110], which point out that MAE may be a promising technique when the whole phenolic fraction of macroalgae is intended for study.…”

Section: Solvent Of Extraction (mentioning

confidence: 99%

The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies

et al. 2019

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The current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly phlorotannins, have gained particular attention due to their specific bioactivities, including antioxidant, antiproliferative, or antidiabetic. Notwithstanding, the characterization of macroalgae phenolic compounds is a multi-step task, with high challenges associated with their isolation and characterization, due to the highly complex and polysaccharide-rich matrix of macroalgae. Therefore, this fraction is far from being fully explored. In fact, a critical revision of the extraction and characterization methodologies already used in the analysis of phenolic compounds from macroalgae is lacking in the literature, and it is of uttermost importance to compile validated methodologies and discourage misleading practices. The aim of this review is to discuss the state-of-the-art of phenolic compounds already identified in green, red, and brown macroalgae, reviewing their structural classification, as well as critically discussing extraction methodologies, chromatographic separation techniques, and the analytical strategies for their characterization, including information about structural identification techniques and key spectroscopic profiles. For the first time, mass spectrometry data of phlorotannins, a chemical family quite exclusive of macroalgae, is compiled and discussed.

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“…In addition, MAE extraction is very suitable for extracting compounds that are not heat resistant (Angiolillo et al, 2015). The MAE method can also help to increase the amount of crude extract in the extraction time and the lower amount of solvent compared to conventional extraction methods (Vinatoru et al, 2017;Yuan et al, 2018;Zhong et al, 2018). In the MAE method, the microwave generated can increase the temperature of the solvent in the material which can cause the cell wall to break and the substances contained in the cell out towards the solvent, so that the yield produced increases (Chemat and Giancarlo, 2013).…”

Section: Original Researchmentioning

confidence: 99%

Application of microwave assisted extraction in extracting Torbangun leaves (Coleus ambonicus, L.) and its effects on polyphenol and flavonoids content

Hendrawan

Pramesi

Rachmawati

et al. 2018

AFSSAAE

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Flavonoids Microwave Assisted Extraction Polyphenols Torbangun Leaves Torbangun leaves (Coleus ambonicus, L.) contain polyphenol compounds, flavonoids and antioxidant compounds that can be obtained by extraction methods. However, with the conventional extraction method it has the disadvantage of long extraction time and requires a lot of solvents. Therefore, this study discusses the use of microwave assisted extraction (MAE) method to extract the leaves of Torbangun. This study uses two treatment factors on MAE i.e. power variations (100, 180 and 300 Watts) and extraction time (1, 2 and 3 minutes). This study aims to analyze the effect of MAE on the content of polyphenol compounds and flavonoids in the extraction process of Torbangun leaf. The results showed that the highest total phenol (4196.59 mg GAE/g extract) was found in the treatment of 300 watt of power with extraction time of 3-minutes with IC50 value of 9.89 mg/ml. The highest total flavonoid value was 300 watt of power with 1-minute extraction time which was 4.54 mg QE/g DW.

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Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase

Cited by 180 publications

References 38 publications

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies

Application of microwave assisted extraction in extracting Torbangun leaves (Coleus ambonicus, L.) and its effects on polyphenol and flavonoids content

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