Microwave‐assisted Four‐component Cascade Reaction: One‐pot Rapid Access in the Metal‐free Synthesis of Fully Substituted Pyrroles

Abstract

A simple and rapid methodology for the synthesis of fully substituted pyrroles was accomplished by the reaction microwave‐assisted from amines, 4‐hydroxycoumarins, and ketones. This protocol proceeds via ketones Csp3−H oxidation Michael addition/ cyclization/ aromatization four‐component cascade reaction affording the fully substituted pyrrole in moderate to excellent yields only in 3 min. Simple reaction conditions, high yields, and compatibility are the advantages of this protocol.

Iodine-Catalyzed Diversity-Oriented Synthesis of 3,4-Heterocycle-Fused Coumarins from 4-Aminocoumarins and Aurones in Different Solvent

“…Indole, amine, 1,3-dicarbonyl compounds, etc. can be used as the nucleophilic reagents to form diverse functionalized [3,4]-fused pyrrolocoumarins . For instance, Das and co-workers disclosed a nanocrystalline CuFe 2 O 4 catalyzed one-pot three-component synthesis of pyrrolocoumarins from amine, glyoxal monohydrate, and 4-aminocoumarin (Scheme a) .…”