Microwave-assisted Friedländer synthesis of quinolines derivatives as potential antiparasitic agents

Recent Advances in Biomimetic Synthesis Involving Cyclodextrins

“…introduced gold catalysed quinoline synthesis under microwave-assisted conditions. Lewis acids (Hu et al, 2003;McNaughton & Miller, 2003;Zhang & Wu, 2007), Bronsted acids (Muscia et al, 2006), molecular iodine (Wu et al, 2006), proline (Jiang et al, 2008), ionic liquids (Dabiri et al, 2008) and transition metals (Martinez et al, 2007;Gabriele et al, 2007;Vieira &Alper, 2007;Cho & Ren, 2007) were some of the catalysts involved in different synthetic protocols for quinoline structural motif. However many of the aforementioned reactions require strong acids or bases, toxic flammable organic solvents, or hazardous/ expensive catalysts and elevated temperatures.…”

Silica-based sulfonic acid (MCM-41-SO3H): a practical and efficient catalyst for the synthesis of highly substituted quinolines under solvent-free conditions at ambient temperature

“…Reports showed that acid catalysts are more effective than base catalysts for this reaction. There has been some development for the synthesis of quinolines derivatives using acid catalysts such as p-toluenesulfonic acid 11 , hydrochloric acid 12,13 , . But, many of these procedures have been highlight led to suffer from various problems such as low yields, harsh reaction conditions, difficulties in workup, expensive reagents, long reaction times, and the use of toxic solvents.…”

Synthesis of new trifluoromethyl-containing cycloalka[b]quinolines derivated from alkoxycycloalkenes

“…Thus, the development of alternative drugs is a continuing and urgent necessity. 1 Quinolines possess important pharmacological properties.…”

“…2 Other well-known methods to obtain quinolines include using microwave as reported by Asís et al 1 or employing ruthenium catalysis as described by Shim and Cho. 8 Recently, Banwell reported the synthesis of some quinolines by an Ullmann coupling mediated by palladium catalysis.…”