2021
DOI: 10.1002/slct.202100165
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Microwave‐Assisted Iron(III)Chloride Catalyzed One‐Pot Michael Addition‐Cyclization for the Synthesis of 6H‐Chromeno[4’,3’:4,5] imidazo[1,2‐a]pyridine

Abstract: An efficient one-pot Michael addition-cyclization reaction has been developed for the synthesis of 6H-chromeno[4',3' : 4,5] imidazo[1,2-a]pyridine under microwave irradiation method. The current protocol paves the way for the synthesis of twenty number of structurally diversified imidazo[1,2-a]pyridines in high yield by the reaction of substituted 2-aryl-3-nitro-2Hchromenes with 2-aminopyridines using anhydrous iron (III)chloride. This current protocol is the first report of the preparation of this medicinal… Show more

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Cited by 14 publications
(6 citation statements)
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References 36 publications
(27 reference statements)
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“…Therefore, continuous efforts have been made to synthesize more chromene‐fused heterocyclic molecules. Encouraged by their continuing research in constructing chromene‐fused heterocycles, Mishra et al [203] . in 2021 reported an anhydrous iron(III) chloride catalyzed efficient one‐pot Michael addition‐cyclization reaction for the synthesis of 6 H ‐chromeno[4′,3′ : 4,5]imidazo[1,2‐ a ]pyridine 271 from 2‐aryl‐3‐nitro‐ 2H ‐chromene 269 and 2‐aminopyridine derivatives 270 under microwave irradiation method in moderate to high yields.…”
Section: Development Of Various Methods Towards the Synthesis Of Imid...mentioning
confidence: 99%
See 1 more Smart Citation
“…Therefore, continuous efforts have been made to synthesize more chromene‐fused heterocyclic molecules. Encouraged by their continuing research in constructing chromene‐fused heterocycles, Mishra et al [203] . in 2021 reported an anhydrous iron(III) chloride catalyzed efficient one‐pot Michael addition‐cyclization reaction for the synthesis of 6 H ‐chromeno[4′,3′ : 4,5]imidazo[1,2‐ a ]pyridine 271 from 2‐aryl‐3‐nitro‐ 2H ‐chromene 269 and 2‐aminopyridine derivatives 270 under microwave irradiation method in moderate to high yields.…”
Section: Development Of Various Methods Towards the Synthesis Of Imid...mentioning
confidence: 99%
“…[202] Therefore, continuous efforts have been made to synthesize more chromene-fused heterocyclic molecules. Encouraged by their continuing research in constructing chromene-fused heterocycles, Mishra et al [203]…”
Section: Microwave-assisted Reactionsmentioning
confidence: 99%
“…This procedure has several notable advantages, including rapid reaction times, ease of operation, and tolerance to a broad range of functional groups. 68…”
Section: Review Synopenmentioning
confidence: 99%
“…17,18 Note that our group has already reported aza/carba-Michael addition reactions with 3-nitro-2H-chromene derivatives and examined the antibacterial properties. [19][20][21] In 2017, Yang et al were the first to report a DCM-mediated catalyst-free sulfa Michael addition reaction involving heteroaromatic thiols and aliphatic nitrostyrene. 22 There have been a few other instances of Michael addition reactions between thiophenol to 1-nitrocyclohexene and various a,b-unsaturated compounds.…”
Section: Introductionmentioning
confidence: 99%