Microwave-assisted methacrylation of chitosan for 3D printable hydrogels in tissue engineering

Zanon, Michael; Chiappone, Annalisa; Garino, Nadia; Canta, Marta; Frascella, Francesca; Hakkarainen, Minna; Pirri, Candido

doi:10.1039/d1ma00765c

Cited by 26 publications

(25 citation statements)

References 79 publications

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“…Chitosan and gelatin were methacrylated, following the previously reported experimental procedure, to make them photocurable [ 33 , 34 ]. The schemes of the methacrylation reactions are reported in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The chitosan (CH) methacrylation was accomplished as previously reported [ 33 ]. Briefly, the CH (1.5 wt%) was solubilized in an acetic acid-water solution (2 wt%), then MA was added (molar ratio NH 2 :MA = 1:1).…”

Section: Methodsmentioning

confidence: 99%

“…Within this framework, we have methacrylated two natural polymers, chitosan, and gelatin, via a previously reported procedure [ 33 , 34 ]. This chemical modification makes these polymers suitable for photopolymerization in water, which is a fast-curing process and an environmentally friendly technique occurring at room temperature that allows achieving crosslinked hydrogels [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

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UV-Cured Chitosan and Gelatin Hydrogels for the Removal of As(V) and Pb(II) from Water

et al. 2022

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In this study, new photocurable biobased hydrogels deriving from chitosan and gelatin are designed and tested as sorbents for As(V) and Pb(II) removal from water. Those renewable materials were modified by a simple methacrylation reaction in order to make them light processable. The success of the reaction was evaluated by both 1H-NMR and FTIR spectroscopy. The reactivity of those formulations was subsequently investigated by a real-time photorheology test. The obtained hydrogels showed high swelling capability reaching up to 1200% in the case of methacrylated gelatin (GelMA). Subsequently, the Z-potential of the methacrylated chitosan (MCH) and GelMA was measured to correlate their electrostatic surface characteristics with their adsorption properties for As(V) and Pb(II). The pH of the solutions proved to have a huge influence on the As(V) and Pb(II) adsorption capacity of the obtained hydrogels. Furthermore, the effect of As(V) and Pb(II) initial concentration and contact time on the adsorption capability of MCH and GelMA were investigated and discussed. The MCH and GelMA hydrogels demonstrated to be promising sorbents for the removal of heavy metals from polluted waters.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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UV-Cured Chitosan and Gelatin Hydrogels for the Removal of As(V) and Pb(II) from Water

et al. 2022

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“…Nevertheless, the most common chemical networking agents, such as formaldehyde [ 35 ], epichlorohydrin [ 36 ], and N,N’-methylenebisacrylamide [ 37 ], are harmful to human and environmental health, and the physical networking methods using the introduction of ionic interactions, hydrogen bonding, and molecular entanglements are not significantly effective for heavy metal ion removal. In the literature, very few works have studied the use of the photocrosslinking process to produce chitosan hydrogels, an environmentally friendly technique to achieve crosslinked hydrogels through the chemical addition of a crosslinker [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

UV-Cured Chitosan-Based Hydrogels Strengthened by Tannic Acid for the Removal of Copper Ions from Water

et al. 2022

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In this work, a new environmentally friendly material for the removal of heavy metal ions was developed to enhance the adsorption efficiency of photocurable chitosan-based hydrogels (CHg). The acknowledged affinity of tannic acid (TA) to metal ions was investigated to improve the properties of hydrogels obtained from natural and renewable sources (CHg-TA). The hydrogel preparation was performed via a simple two-step method consisting of the photocrosslinking of methacrylated chitosan and its subsequent swelling in the TA solution. The samples were characterized using ATR-FTIR, SEM, and Folin–Ciocalteu (F&C) assay. Moreover, the mechanical properties and the ζ potential of CHg and CHg-TA were tested. The copper ion was selected as a pollutant model. The adsorption capacity (Qe) of CHg and CHg-TA was assessed as a function of pH. Under acidic conditions, CHg-TA shows a higher Qe than CHg through the coordination of copper ions by TA. At an alkaline pH, the phenols convert into a quinone form, decreasing the Qe of CHg-TA, and the performance of CHg was found to be improved. A partial TA release can occur in the copper solution due to its high hydrophilicity and strong acidic pH conditions. Additionally, the reusability of hydrogels was assessed, and the high number of recycling cycles of CHg-TA was related to its high mechanical performance (compression tests). These findings suggest CHg-TA as a promising green candidate for heavy metal ion removal from acidic wastewater.

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“…Hydrogels and related soft materials are highly studied for their use in tissue engineering, regenerative medicine and other biomedical applications such as use as cell culture media. [1][2][3][4][5][6] Their biocompatibility, and flexible/stretchable nature also make hydrogels attractive candidates for use in soft robotics. 7,8 For both these and many other applications, an understanding of the mechanical properties and their spatial relationships within these materials is crucial.…”

Section: Introductionmentioning

confidence: 99%

Automated analysis of soft material microindentation

et al. 2022

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Microwave-assisted methacrylation of chitosan for 3D printable hydrogels in tissue engineering

Abstract: The microwave-assisted methacrylation of chitosan is studied. The control of the process parameters allows tuning the methacrylation degree and thus the hydrogel properties after photocuring. The resulting chitosan is 3D printable and biocompatible.

Cited by 26 publications

References 79 publications

UV-Cured Chitosan and Gelatin Hydrogels for the Removal of As(V) and Pb(II) from Water

UV-Cured Chitosan and Gelatin Hydrogels for the Removal of As(V) and Pb(II) from Water

UV-Cured Chitosan-Based Hydrogels Strengthened by Tannic Acid for the Removal of Copper Ions from Water

Automated analysis of soft material microindentation

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