Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles

Abstract

BackgroundPyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation.ResultsMicrowave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5-diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines.ConclusionThe present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.

A Green Approach Toward Quinoxalines and Bis -Quinoxalines and Their Biological Evaluation Against A431, Human Skin Cancer Cell Lines

“…In this context, development of synthetic methods under solventless condition or the replacement of hazardous solvents with environmentally benign solvents, such as water, has become an important and popular research topic in recent years. The authors' laboratory has been actively engaged in developing green synthetic protocols for a long time [59,[63][64][65][66][67][68][69][70][71][72]. We have tested this present ecofriendly route for the synthesis of quinoxalines with different solvents as well as under solvent-free conditions.…”

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

“…To exemplify, N-arylpyrroles (35) e Fig. 5, have been prepared in a reaction of 2,5-dimethoxytetrahydrofuran with a variety of amines, (aromatic, aliphatic, polyaromatic and heteropolyaromatic amines) in aqueous solution and using pole(styrene sulfonate) as a catalyst [83]. Due to the simplicity of the procedure, the products are easily isolated and, in this case, can be directly tested for anticancer activity.…”

Synthesis Strategies and Biological Value of Pyrrole and Pyrrolopyrimidine

“…Shin-ichi Naya et al 63 Many authors [64][65][66][67] reported another approach to transformation of 2,5-dimethoxytetrahydrofuran to pyrrole derivatives 65 in presence of acid either by stirring at room temperature 64 , using microwav 65,66 or ultrasound conditions 67…”