“…In addition, 2-(acetoxymethyl)-, 2-(methoxymethyl)and 2-(phenoxymethyl)aziridines were treated with LiAlH 4 under microwave irradiation, giving rise to either b-amino alcohols, isopropylamines or 1-methoxypropan-2-amines depending on the reaction conditions. 36 However, Uneyama and coworkers 37 have reported the unsuccessful transformation of chiral 2-(trifluoromethyl)aziridines 81 toward ring-opened products by using Lewis acids as catalysts and aliphatic amines as nucleophiles (Scheme 27). In this case, the reduced basicity of the aziridine nitrogen atom due to the strong electron-withdrawing effect of the CF 3 group clearly hampered the formation of aziridiniumlike intermediates.…”