Microwave-assisted solvent-free ring-opening polymerization of ε-caprolactone initiated by n-butyltin(IV) chlorides

Efficient Flow Synthesis of Glycidyl Ether Using BuSnCl3 as a Mild Lewis Acid

“…In this paper, we report on the flow synthesis of glycidyl ethers via the halohydrin synthesis from alcohols and epichlorohydrin, for which we found BuSnCl 3 acts as a very mild Lewis acid catalyst to ensure a highly selective reaction that gives the desired chlorohydrins. 5 The present flow protocol has the advantages of efficient micro-mixing and precise temperature control, which would contribute to suppressing undesired side reactions. 6,7 The reaction of 2-ethylhexanol (1a) with epichlorohydrin (2) was investigated as a model reaction (Table 1), in which we tested three liquid-type Lewis acids, BuSnCl 3 , BF 3 •OEt 2 , and SnCl 4 .…”