Microwave‐Assisted Solvent‐Free Synthesis of 3‐[(4‐Substituted Piperazin‐1‐yl)alkyl] Imidazo[2,1‐b][1,3]benzothiazol‐2(3H)‐ones as Serotonin₃ (5‐HT₃) Receptor Antagonists.

Abstract

Pyrimidine derivatives R 0510 Microwave-Assisted Solvent-Free Synthesis of 3-[(4-Substituted Piperazin--1-yl)alkyl] Imidazo[2,1-b][1,3]benzothiazol-2(3H)-ones asSerotonin3 (5-HT3) Receptor Antagonists. -Compound (V) shows the highest antagonistic activity of all tested compounds against the target receptor. -(MAHESH*, R.; PERUMAL, R. V.; PANDI, P. V.; Pharmazie 60 (2005) 6, 411-414; Dep. Pharm., Birla Inst. Technol. Sci., Pilani 333 031, India; Eng.) -C. Oppel

Synthesis and Biological Evaluation of Novel Substituted 4‐Anilinoquinazolines as Antitumor Agents

“…And 9i was prepared by 3‐(methylsulfonyl)propyl4‐methyl‐benzene‐sulfonate coupling with 8a . Then, we used the 9a to react with phosphorus oxychloride, directly converted to 9j by treating with sodium methanolate–methanol solution and converted to 9k by treating with sodium ethoxide–ethanol solution 24,25.…”

“…4-(2-Chloroethyl)morpholine was reacted with 6a, 6b, 8a to prepare 9c-e. Requisite boc-protected amino acids were coupled with 6c to give 9f-h. And 9i was prepared by 3-(methylsulfonyl)propyl4-methyl-benzene-sulfonate coupling with 8a. Then, we used the 9a to react with phosphorus oxychloride, directly converted to 9j by treating with sodium methanolate-methanol solution and converted to 9k by treating with sodium ethoxide-ethanol solution (24,25).…”