Microwave‐Assisted Synthesis and Spectral Characterization of Biological Activity Heterocyclic Thiosemicarbazone and Its Organometallic Derivatives

Abstract

The thiosemicarbazone coordinates to metal through the thionic sulfur and the azomethine nitrogen. The thiosemicarbazone was obtained by the thiosemicarbazide with 3‐acetyl‐2,5‐dimethylfuran by microwave irradiation. Metal complexes were prepared by the reaction of thiosemicarbazone with metal salts. IR, 1H, 13C NMR, FAB‐mass spectroscopic methods, and elemental analysis elucidated the structure of these compounds. The antibacterial activity of these compounds were first tested in vitro by the disk diffusion assay against two Gram‐positive and two Gram‐negative bacteria, and then minimum inhibitory concentration was determined, chloramphenicol as reference drug. The results showed that copper (II) metal complex of the thiosemicarbazone (1.1) is a better inhibitor as compared with chloramphenicol.

Synthesis of Levoglucosenone‐derived Thiosemicarbazones as Promising Antituberculosis Agents

“…These functional groups were initially studied as anti-tuberculosis agents, [22] but over time it was found that they represent privileged motives in medicinal chemistry, exhibiting an extensive range of biological activities, including antifungal, antitumor, hypnotic, antiviral and antimalarial effects. [23][24][25][26] Additionally, due to the presence of lone pair electrons in the nitrogen and the sulfur atoms, TSC can serve as versatile ligands with a broad variety of coordination modes, exerting an important role in biological processes. [27] The first clinically approved drug of this compound class is Thioacetazone (Figure 1), [24,28] which has been wildly used in the past as a companion drug, together with first-line TB medications.…”