Microwave-Assisted Synthesis, Characterization, and Biological Evaluation of Phenylacrylamide Derivatives of Triazoles Derived From Oxazolones

Abstract

Objective: The aim of the present study is to synthesize novel phenylacrylamide derivatives as potent bioactive agents.Methods: Novel N-(3-(4H-1,2,4-triazol-4-ylamino)-3-oxo-1-arylidene prop-2-yl) benzimidic acids (7a-c) have been synthesized by the reaction of 4-(arylidene)-2-phenyloxazol-5(4H)-ones (5a-c) with 4-amino-1, 2, 4-triazole (6) in the presence of anhydrous sodium acetate in glacial acetic acid. Titled compounds (7a-c) were obtained in good yields using microwave technology which resulted in dramatic reductions in reaction times leading to the formation of phenylacrylamide derivatives (7a-c) at a faster rate.Results: The structures of the newly synthesized compounds were characterized by Fourier-transform infrared, 1H NMR, 13C NMR, and mass spectral studies. This method can be an efficient method for the synthesis of phenylacrylamide derivatives (7a-c).Conclusion: All the final compounds were screened for their antimicrobial and antioxidant activities and found to be biologically active. Among all the compounds, 7b was found to be potent antimicrobial and antioxidant.

Energy Savings on Curcumine Derivative Gamavuton-0 Synthesis Using Microwave Irradiation

“…Some Schiff bases were synthesized in a very short time and excellent yield when the synthesis was conducted under microwave irradiation [7]. The phenyl acrylamide derivatives as potential active agent were also successfully synthesized under microwave irradiation [8]. Energy efficiency in the microwave-assisted solid-state synthesis of cobalt aluminate pigment was also calculated.…”

Application of Imidazole-Based Ionic Liquids in Microwave-Assisted Extraction of Trans-Resveratrol From Gnetum Gnemon L. Seeds

“…Several advanced techniques such as supercritical fluid extraction, ultrasonic-assisted extraction, and microwave-assisted extraction (MAE) have been used in attempts to improve the efficiency of extraction methods by minimizing the extraction time and solvent usage while maximizing yield. Although all of these methods have their own requirements, a comparative analysis showed that MAE is faster, uses less material, and requires less solvent [7,9,11].…”