Microwave assisted synthesis of 2,3-dihydro-4H-benzo[4,5]thiazolo[3,2-a]furo[2,3-d] pyrimidin-4-ones by radical addition of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a] pyrimidin-4-ones to various conjugated alkenes and dienes mediated Mn(OAc)3

Yılmaz, Mehmet; Inal, Aslı Ustalar

doi:10.1016/j.tet.2022.132806

Tetrahedron

2022

DOI: 10.1016/j.tet.2022.132806

|View full text |Cite

Microwave assisted synthesis of 2,3-dihydro-4H-benzo[4,5]thiazolo[3,2-a]furo[2,3-d] pyrimidin-4-ones by radical addition of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a] pyrimidin-4-ones to various conjugated alkenes and dienes mediated Mn(OAc)3

Mehmet Yılmaz

Aslı Ustalar Inal

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article4

Relationship

Self Cite1

Independent3

Authors

Journals

Cited by 4 publications

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Microwave assisted synthesis, acetylcholinesterase inhibition and molecular docking studies of furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐one derivatives

Yalduz,

Sarı,

Yılmaz

2024

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

A series of phenyl, substituted phenyl and thiophene bearing dihydrofuropyrimidin‐4‐ones (3a‐p) were synthesized by Mn(OAc)3 mediated, microwave irradiated radical cyclizations of 2‐hydroxy‐pyridopyrimidin‐4‐one derivatives (1a‐j) with substituted phenylvinylthiophenes (2a‐c) at 70°C in 2 min. Compounds 3a‐j was obtained between 28% and 66% yields. Molecular structures of 3a‐p were determined by 1H NMR, 13C NMR, 19F NMR, FTIR and HRMS techniques. Inhibitory activity of 3a‐p were evaluated against Acetylcholinesterase (AChE) and inhibition results of these compounds showed that the compounds had good inhibition with IC50 values between 0.52 and 3.77 μM. In addition, molecular docking studies were carried out on the most potent inhibitory compounds 3d (IC50 = 0.64 μM), 3p (IC50 = 0.52 μM) and standart drug Donepezil. The binding energies for 3d, 3p and Donepezil are −9.12, −10.08 and −12.65 Kcal/mol, respectively. Based on these results, it was determined that, compounds 3d and 3p are promising AChE inhibitors.

show abstract

Microwave assisted synthesis, acetylcholinesterase inhibition and molecular docking studies of furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐one derivatives

Yalduz,

Sarı,

Yılmaz

2024

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

show abstract

Microwave Assisted Synthesis of 2,3‐Dihydro‐4H‐ furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐ones and furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐one

Yalduz

Yılmaz

2023

ChemistrySelect

Self Cite

View full text Add to dashboard Cite

In this work, furo[2,3d]pyrido [1,2-a]pyrimidin-4-ones were obtained by microwave assisted radical cyclizations of 2-hydroxy-4H-pirido[1,2a]pirimidin-4-ones with conjugated alkenes and phenylacetylene via Mn(OAc) 3. Conventional heating and microwave irradiated reaction types were compared using parameters like temperature, time and molar ratios to determine best reaction condition. Obtained compounds were purified by chromatographic methods and characterized by spectroscopic techniques ( 1 H NMR, 13 C NMR, HRMS, FTIR). Also, to determine the exact configuration and regioselectivity of isolated compounds, XRD analysis were performed.

show abstract

Microwave assisted synthesis and AChE inhibition studies of novel thiazolo and thiadiazolo [3,2-a]pyrimidinone fused dihydrofuran compounds

2023

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Microwave assisted synthesis of 2,3-dihydro-4H-benzo[4,5]thiazolo[3,2-a]furo[2,3-d] pyrimidin-4-ones by radical addition of 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a] pyrimidin-4-ones to various conjugated alkenes and dienes mediated Mn(OAc)3

Cited by 4 publications

References 110 publications

Microwave assisted synthesis, acetylcholinesterase inhibition and molecular docking studies of furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐one derivatives

Microwave assisted synthesis, acetylcholinesterase inhibition and molecular docking studies of furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐one derivatives

Microwave Assisted Synthesis of 2,3‐Dihydro‐4H‐ furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐ones and furo[2,3‐d]pyrido[1,2‐a]pyrimidin‐4‐one

Microwave assisted synthesis and AChE inhibition studies of novel thiazolo and thiadiazolo [3,2-a]pyrimidinone fused dihydrofuran compounds

Contact Info

Product

Resources

About