Microwave-Assisted Synthesis of 3-Substituted Indole Derivatives via Three-Component Domino Reaction

An Efficient Synthesis of Acenaphtho[1,2-b]indole Derivatives via Domino Reaction

“…Domino (cascade) reactions are promising and powerful tools in organic and medical chemistry because of their high atom economy, highly complex and diverse products, efficiency in forming multiple bonds, and environmental friendliness [ 22 ]. Consequently, domino reactions have often been used for the construction of complex heterocycles [ 23 , 24 , 25 , 26 , 27 , 28 ]. As part of our program to develop new methods for the construction of important heterocycles by domino reactions [ 29 , 30 , 31 , 32 ], we report herein an efficient synthesis of acenaphtho[1,2- b ]indole derivatives via a domino reaction using l -proline as the catalyst.…”