Microwave-assisted synthesis of fused tricyclic pyrazino[1,2-a]indole derivatives

DBU-Catalyzed Alkyne–Imidate Cyclization toward 1-Alkoxypyrazino[1,2-a]indole Synthesis

“…Regarding natural occurrence, secondary metabolites of marine flora and fauna exhibiting antibacterial and antiproliferative activities incorporate pyrazino­[1,2- a ]­indole and methoxy­pyrazine moieties (Figure ). The aforementioned properties render pyrazino­indoles an interesting synthesis target . Recent synthesis examples include alkyne hydroamination, a two-step Ugi–alkyne hydroamination reaction sequence, and bromo­lactamization of N -allylindole-2-carbamide .…”

Experimental and computational evidence for KOt-Bu-promoted synthesis of oxopyrazino[1,2-a]indoles

“…In spite of the efficacy of pyrazino [1,2a]indoles, literature lacks adequate reports for their synthesis. [20][21][22][23][24] Hence, development of novel, efficient, easy, and rapid synthetic approaches is still a common research area. Intramolecular cyclization of several 2-carbonyl-1propargylindoles in the presence of ammonia was developed by Abbiati et al 20 The reaction was investigated in various heating conditions in the presence of different metal catalysts.…”