Microwave assisted synthesis of indole-annulated dihydropyrano[3,4-c]chromene derivatives via hetero-Diels–Alder reaction

Jha, Mukund; Guy, Stephanie; Chou, Ting-Yi

doi:10.1016/j.tetlet.2011.06.052

Cited by 35 publications

(25 citation statements)

References 24 publications

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“…In this context, Jha et al [126] reported an efficient two-step synthesis of indole-annulated dihydropyrano [3,4-c]chromene derivatives 127 via the Knoevenagel condensation of indolin-2-ones 124 with O-propargylated salicylaldehyde derivatives 125, followed by a microwave-assisted intramolecular hetero-Diels-Alder reaction of the resulting (Z)-3-(2-(prop-2-ynyloxy)benzyl-idene)indolin-2-ones 126 in the presence of CuI (20 mol %) (Scheme 27). In this latter step, the unreactive terminal alkyne is activated by copper through the formation of a π complex.…”

Section: Benzopyrones: Coumarins and Chromonesmentioning

confidence: 99%

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Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

et al. 2016

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This review describes the formation of six-membered heterocyclic compounds and their fused analogues under microwave activation using modern organic transformations including cyclocondensation, cycloaddition, multicomponents and other modular reactions. The review is divided according to the main heterocycle types in order of increasing complexity, starting with heterocyclic systems containing one, two and three heteroatoms and their fused analogues. Recent microwave applications are reviewed, with special focus on the chemistry of bioactive compounds. Selected examples from the 2006 to 2015 literature are discussed.

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Section: Benzopyrones: Coumarins and Chromonesmentioning

confidence: 99%

“…In this context, Jha et al [126] reported an Scheme 26. Mechanistic study of the thiochromones synthesis reported by Wen et al [125].…”

Section: Benzopyrones: Coumarins and Chromonesmentioning

confidence: 99%

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

et al. 2016

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“…Heterocyclic compounds have drawn special attention in organic chemistry because of their abundance in natural products and their diverse biological properties [1]. Pyrimidine and its derivatives have been recognized as important heterocyclic compounds due to their variety of chemical and biological significance to medicinal chemistry [2][3].…”

Section: Ultrasound Irradiationmentioning

confidence: 99%

“…During recent years there have been intense investigations on fused thiadiazole and pyrimidine systems. Literature survey revealed that [1,3,4] thiadiazolo [3,2-a]pyrimidine nucleus is associated with diverse pharmacodynamic and chemotherapeutic activities [4,5], including antimicrobial [6,7,8,5] and antitumor activities [4,6], herbicidal, antifungal, neuramidase inhibitors. 1,3,4-thiadiazolo [3,2-a]pyrimidines have been used as key building blocks for the preparation of a variety of novel bioactive agents.…”

Section: Ultrasound Irradiationmentioning

confidence: 99%