Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities

Baba, N.H. Kumar; Ashok, D.; Rao, B. Appa; Sarasija, M.; Murthy, N. Y. S.

doi:10.1007/s10593-018-2323-x

Cited by 3 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The derivatives 25b , 25c , and 25d demonstrated superior growth inhibition against a Gram-positive B. subtilis strain. Antibacterial activity of the studied compounds against B. subtilis and M. bovis strains was enhanced by the presence of Br and F atoms in the ortho position of aromatic rings …”

Section: Synthesis Of Cu-catalyzed Heterocyclic Moieties Via Microwav...mentioning

confidence: 95%

See 1 more Smart Citation

Copper Catalyzed Synthesis of Heterocyclic Molecules via C–N and C–O Bond Formation under Microwaves: A Mini-Review

Jena

Chanda

2023

ACS Omega

View full text Add to dashboard Cite

Heterocyclic moieties play a significant role in the field of drug discovery. C−N and C−O bond formation reactions are the primary synthetic sequence for the generation of heterocyclic molecules. The generation of C−N and C−O bonds involves the use of mostly Pd or Cu catalysts although other transition metal catalyst's are also involved. However, in C−N and C−O bond formation reactions, several problems were faced such as catalytic systems containing costly ligands, lack of substrate scope, lots of waste generation, and high temperature conditions. So it is imperative to uncover new eco-friendly synthetic strategies. In view of enormous drawbacks, it is important to develop an alternate microwave-assisted synthesis of heterocycles via C−N and C−O bond formation, which provides a short reaction time, tolerance for functional groups, and less waste production. Numerous chemical reactions have been accelerated using microwave irradiation which provides a cleaner reaction profile, lower energy consumption, and higher yields. This review article highlights a comprehensive overview on the potential application of microwave assisted synthetic routes for the synthesis of diverse heterocycles via mechanistic pathways covering the year ranges from 2014 to 2023, along with possible biological interests.

show abstract

Section: Synthesis Of Cu-catalyzed Heterocyclic Moieties Via Microwav...mentioning

confidence: 95%

“…Antibacterial activity of the studied compounds against B. subtilis and M. bovis strains was enhanced by the presence of Br and F atoms in the ortho position of aromatic rings. 13 …”

Section: Synthesis Of Cu-catalyzed Heterocyclic Moieties Via Microwav...mentioning

confidence: 99%

Copper Catalyzed Synthesis of Heterocyclic Molecules via C–N and C–O Bond Formation under Microwaves: A Mini-Review

Jena

Chanda

2023

ACS Omega

View full text Add to dashboard Cite

show abstract

“…These compounds were synthesized starting from O,O-diacetyl dioxime and aryl-isothiocyanates under microwave irradiation. The reaction produced higher yield within short reaction time compared to conventional heating [78]. A catalytic amount (20 mol %) of CuI, in the presence of Cs 2 CO 3 as a base and dioxane as solvent, the resulting mixture was then heated in a microwave oven at 100 • C for 15-25 min to produce benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives in high yields, Scheme 49.…”

Section: Synthesis Of Heterocyclic Systemsmentioning

confidence: 99%

Recent Advances in Microwave-Assisted Copper-Catalyzed Cross-Coupling Reactions

Baqi

2020

Catalysts

View full text Add to dashboard Cite

Cross-coupling reactions furnishing carbon–carbon (C–C) and carbon–heteroatom (C–X) bond is one of the most challenging tasks in organic syntheses. The early developed reaction protocols by Ullmann, Ullman–Goldberg, Cadiot–Chodkiewicz, Castro–Stephens, and Corey–House, utilizing elemental copper or its salts as catalyst have, for decades, attracted and inspired scientists. However, these reactions were suffering from the range of functional groups tolerated as well as severely restricted by the harsh reaction conditions often required high temperatures (150–200 °C) for extended reaction time. Enormous efforts have been paid to develop and achieve more sustainable reaction conditions by applying the microwave irradiation. The use of controlled microwave heating dramatically reduces the time required and therefore resulting in increase in the yield as well as the efficiency of the reaction. This review is mainly focuses on the recent advances and applications of copper catalyzed cross-coupling generation of carbon–carbon and carbon–heteroatom bond under microwave technology.

show abstract

Tricyclic Systems: Central Carbocyclic Ring With Fused Five-Membered Rings

Conboy¹,

Aldabbagh²

2022

Comprehensive Heterocyclic Chemistry IV

View full text Add to dashboard Cite

Microwave-assisted synthesis of novel benzodifuran-based bis(N-(het)arylthiazol-2-amine) derivatives and their antibacterial and antimycobacterial activities

Cited by 3 publications

References 11 publications

Copper Catalyzed Synthesis of Heterocyclic Molecules via C–N and C–O Bond Formation under Microwaves: A Mini-Review

Copper Catalyzed Synthesis of Heterocyclic Molecules via C–N and C–O Bond Formation under Microwaves: A Mini-Review

Recent Advances in Microwave-Assisted Copper-Catalyzed Cross-Coupling Reactions

Tricyclic Systems: Central Carbocyclic Ring With Fused Five-Membered Rings

Contact Info

Product

Resources

About