Microwave‐Assisted Synthesis of Positional Isomeric Dihydro‐triazolo‐pyrimido‐acridines and Biological studies

Abstract

Microwave synthetic methodologies were proposed for the preparation of positional isomeric dihydro‐triazolo‐pyrimido‐acridines, 3 a‐j and 9 a‐h via friedlander synthesis using response surface methodology (RSM). The advantages of these methodologies over conventional methods are it provides good yields with short reaction times. Free radical scavenging and antifungal studies were performed for compounds 3 a‐j and 9 a‐h. The results of antioxidant assay revealed that compounds 3 c, 3 d and 9 b exhibited excellent property whereas compounds 3 a and 9 a showed significant antifungal property against Aspergillus flavus (A.flavus) and Aspergillus niger (A. niger).

Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry

“…Subashini and group were reported (Sompalle et al, 2020), 7‐chloro‐3,4‐dihydro‐9‐phenyl‐2‐[(pyridin‐2yl) methylen]acridin‐1(2 H )‐one, 52a was prepared by using 7‐chloro‐3,4‐dihydro‐9‐phenylacridin‐1(2 H )‐one ( 47 ) and picolinaldehyde in the presence of KOH at room temperature (Scheme 12). The efficacy of larvicidal and repellent activity of synthesized 47 and 51a against the early fourth instar larvae of filariasis vector, Culex quinquefasciatus , and Japanese encephalitis vector, Culex gelidus (Diptera: Culicidae).…”

“…Subashini and group were reported (Sompalle et al, 2020), 7-chloro-3,4-dihydro-9-phenyl-2-[(pyridin-2yl) methylen]acridin-1(2H)-one, 52a was prepared by using…”

Three‐component one‐pot synthesis of pyrazino[2,3‐a]acridine derivatives under catalyst‐free conditions

“…[ 9 ] Therefore, many novel procedures have been developed to the synthesis of acridine derivatives in recent years. [ 10–21 ]…”

Synthesis, Characterization and Biological Evaluation of Novel Acridine Derivatives for Anti-Inflammatory and Analgesic Activities

“…It is well documented that the semi planar heterocyclic structure of the acridine makes it to interact appreciably with different biomolecular targets. Acridine and its derivatives are reported with activities like anti-inflammatory [2,3] , anti-cancer [4][5][6][7] , anti-microbial [8,9] , anti-tubercular [10,11] , anti-parasitic [12] , anti-malarial [13][14][15] , antiviral [16,17] , fungicidal [18,19] larvicidal [20][21][22] and anthelmintic [23] activities. Furthermore, acridines are utilised as dyes, fluorescent dyes for visualization of biomolecules and in laser technologies.…”