2009
DOI: 10.1002/cjoc.200990287
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Microwave‐assisted Synthesis of Pyrazolo[4,3‐f]quinolin‐7‐one Derivatives via Multi‐component Reactions

Abstract: A series of new pyrazolo [4,3-f]quinolin-7-one derivatives were synthesized by multi-component reactions of equimolar amount of aromatic aldehydes with 2,2-dimethyl-1,3-dioxane-4,6-dione and 1H-indazol-5-amine in ethylene glycol without catalyst under microwave irradiation. This one-pot protocol has the advantage of good yields, simple workup procedure and shorter reaction time.

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Cited by 9 publications
(4 citation statements)
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“…[34] Later on, nine examples of new pyrazolo[4,3-f]quinolin-7-ones 16 were synthesized by multi-component reactions of equimolar amount of aromatic aldehydes with 2,2-dimethyl-1,3-dioxane-4,6-dione and 1H-indazol-5-amine in ethylene glycol without catalyst under microwave irradiation (Scheme 13). [35] A similar method to produce indeno[2,1-f]quinolin-3(2H)-one derivatives has been described by the same group. [36] In 2010, Tu and Li reported multicomponent domino reactions (MDRs) for the synthesis of spiro{pyrazolo [1,3]-dioxanopyridine}-4,6-diones 17, and spiro{isoxazolo [1,3] dioxanopyridine}-4,6-diones 17 (Scheme 14).…”
Section: Multicomponent Reactions Involving Cyano Compoundsmentioning
confidence: 99%
“…[34] Later on, nine examples of new pyrazolo[4,3-f]quinolin-7-ones 16 were synthesized by multi-component reactions of equimolar amount of aromatic aldehydes with 2,2-dimethyl-1,3-dioxane-4,6-dione and 1H-indazol-5-amine in ethylene glycol without catalyst under microwave irradiation (Scheme 13). [35] A similar method to produce indeno[2,1-f]quinolin-3(2H)-one derivatives has been described by the same group. [36] In 2010, Tu and Li reported multicomponent domino reactions (MDRs) for the synthesis of spiro{pyrazolo [1,3]-dioxanopyridine}-4,6-diones 17, and spiro{isoxazolo [1,3] dioxanopyridine}-4,6-diones 17 (Scheme 14).…”
Section: Multicomponent Reactions Involving Cyano Compoundsmentioning
confidence: 99%
“…[16][17][18] Overall, it is clear that the development of new efficient methods to synthesize N-heterocycles with structural diversity is a major interest of modern synthetic organic chemists. [19][20][21][22][23][24] In 2014, several 1H-pyrazolo[1,2-a]pyridazine-5,8-diones were synthesized under reflux conditions through the catalytic effect of triethanolamine, and their antibacterial properties were evaluated. For example, compounds A and B (Scheme 1) were found to be active against Shigella boydii.…”
Section: Introductionmentioning
confidence: 99%
“…16–18 Overall, it is clear that the development of new efficient methods to synthesize N-heterocycles with structural diversity is a major interest of modern synthetic organic chemists. 19–24…”
Section: Introductionmentioning
confidence: 99%
“…Multicomponent reactions (MCRs) have emerged as an important tool for building of diverse and complex organic molecules through carbon-carbon and carbon-heteroatom bond formations taking place in tandem manner [3]. Particularly, in the last three decades a number of three- and four-component reactions have been developed [46]. …”
Section: Introductionmentioning
confidence: 99%