Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Azarifar, Davood; Ghasemnejad, Hassan

doi:10.3390/80800642

Cited by 85 publications

(43 citation statements)

References 21 publications

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“…Chalcones are a,b-unsaturated ketones which constitute an important group of natural products that serve as precursors for the synthesis of various heterocyclic compounds like pyrimidines, imidazoles, 1) pyrazoles, 2) 2-pyrazolines 3,4) and flavonoids. 5,6) Chalcones, either natural or synthetic, are known to exhibit various biological activities such as anti-inflammatory, 7,8) antifungal, [9][10][11][12] antioxidant, [13][14][15][16] antimalarial, [17][18][19][20] antituberculosis, 21) analgesic, 22) anti-human immunodeficiency virus (HIV) 23) and antitumor activities.…”

mentioning

confidence: 99%

Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones

et al. 2010

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Thirty eight heterocyclic chalcones were synthesized by condensing formylquinolines with diverse methyl arylketones. The target compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. The X-ray crystallographic study of (2E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one (1p) was also performed for the structure confirmation. The title compounds were screened for anti-microbial and antileishmanial activities. The compounds 1c-e, 1g, 1j-m, 1p, 1r-s, 2g, 2j-p, and 2r-s were found potentially active antileishmanial agents, while 1f-i, 1l, 1o-p, 2f-i, 2l, and 2o-p showed remarkable antibacterial activity. Only compounds 1g and 2g-h exhibited significant antifungal activity.

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confidence: 99%

Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones

et al. 2010

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“…The magnitude of the process energy that gives the highest yield is 8.4 kJ. The use of microwave radiation was also performed by Azarifar [15] for condensation reaction yielding several products with 300 watt power for several minutes and 80-95% yield. However, the effect of energy does not have an impact on product purity based on HPLC data.…”

Section: Synthesis Process Conditions Asymmetric Curcumin Analoguesmentioning

confidence: 99%

The Influence of Process Energy on the Yield of Asymmetric Curcumin Analog from Cullilawan Oil

Kapelle¹,

Irawadi²,

Rusli³

et al. 2017

IOSR JAC

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“…18) Condensation of acetylarenes with benzaldehydes under microwave irradiation affords [80] chalcones which undergo facile and clean cyclizations with hydrazines (RNHNH 2 , R=H, Ph, Ac) to afford 3,5-arylated 2-pyrazolines in quantitative yields, also under microwave irradiation and in the presence of dry AcOH as cyclizing agent. This is actually an example of Claisen-Smith reaction under MW irradiation.…”

Section: Microwave Assisted Organic Synthesismentioning

confidence: 99%

Microwave Reactors: A Brief Review on Its Fundamental Aspects and Applications

Rana¹,

Rana²

2014

OALib

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Improved laboratory protocols for convenient and rapid transformations are highly desired in modern synthetic chemistry. Microwave irradiated reactions have received considerable attention in recent years and it is a subject of intense discussion in the scientific community. Microwave heating is more efficient in terms of the energy used, produces higher temperature homogeneity and is considerably more rapid than conventional heating methods. This technique as an alternative to conventional energy sources for introduction of energy into reactions has become a recognized practical method in various fields of chemistry. Microwave-assisted organic synthesis (MAOS) is known for the spectacular accelerations produced in many reactions as a consequence of the increased heating rate, a phenomenon that cannot be easily reproduced by classical heating means. As a result, higher yields, milder reaction conditions and shorter reaction times can often be attained. Its specific heating method attracts extensive interest not only because of rapid volumetric heating, but also for suppressed side reactions, energy saving, decreased environmental pollutions and safe operations. In this review, we will try to represent an overview on origin and fundamental features of microwave ovens and its usefulness in MAOS.

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Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines

Cited by 85 publications

References 21 publications

Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones

Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones

The Influence of Process Energy on the Yield of Asymmetric Curcumin Analog from Cullilawan Oil

Microwave Reactors: A Brief Review on Its Fundamental Aspects and Applications

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