Microwave-assisted synthesis of some new 1,2,3-triazole derivatives and their antimicrobial activity

A Recent Overview of 1,2,3-Triazole-Containing Hybrids as Novel Antifungal Agents: Focusing on Synthesis, Mechanism of Action, and Structure-Activity Relationship (SAR)

“…e compounds were evaluated against two fungi (Aspergillus flavus and Aspergillus niger) using Nystatin as a standard medicine. Compounds 116a and 116b showed a better zone of inhibition, whereas compounds 116c-f exhibited a similar zone of inhibition comparable to the standard drug against the tested fungal strains (Figure 55) [120].…”

Thymol as an Interesting Building Block for Promising Fungicides against Fusarium solani

“…In brief, the facile one-pot CuAAC methodology was used to prepare 3d – l , through Huisgen’s 1,3-dipolar cycloaddition between alkyne and azide, which can be performed in water with an organic cosolvent. The microwave-assisted technique had become a landmark and substantial contribution to mantain the environment by decreasing the waste as well, as it gives a useful internal heat transfer that shortens the reaction time and increases the rate of reaction and yield. − …”

Green synthesis of 1,4-disubstituted 1,2,3-triazoles: a sustainable approach

“…Ashok and co-workers detailed the design and synthesis of a series of new 1,4-disubstituted 1,2,3-triazole derivatives, specifically 1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl) ethanone O-((1-aryl-1H-1,2,3-triazol-4-yl)methyl) derivatives. This synthesis was accomplished through Cu(I) catalyzed 1,3dipolar cycloaddition of alkynes and organic azides, known as the click reaction, employing conventional and µw irradiation methods 192 in DMF : H 2 O (1 : 3), as depicted in Table 7, entry (16). µw irradiation resulted in higher yields within a shorter time, requiring minimal purification, and employed CuI as a cost-effective and readily available catalyst.…”