Microwave has been found as an efficient heating method in chemical industry. However, in present days the interaction between microwave and chemical reactions has not been deeply understood, which restricts a wider application of high power microwave in chemical industry. In this paper, the key problems of interaction between microwave and chemical reaction are investigated, such as complex effective permittivity of chemical reaction, simulation of microwave heating on chemical reaction and non-thermal effect of microwave, which will enhance further knowledge of the mechanism of interaction between microwave and chemical reaction. Moreover, such an analysis is beneficial for handling with difficulties in application of microwave chemical industry.