Microwave Induced Synthesis and Antibacterial Activity of Cephalosporin Derivatives Using Solid Support

Kidwai, Mazaahir; Sapra, Pooja; Bhushan, Kumar R.; Misra, Preeti; Saxena, Rajendra Kumar; Gupta, Rani; Singh, Manoj Kumar

doi:10.1006/bioo.2001.1224

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…5; 111). 69 The synthesis of anticarcinogenic isoflavones (Fig. 6; 113), 70 the antileukaemic alkaloid, convolutamydine-A (Fig.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

The Impact of Microwave Irradiation Reaction in Medicinal Chemistry: A Review

Pal¹,

Gayen²

2021

Orient. J. Chem

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The present review collects an update of the reactions in the area of medicinal chemistry using microwave irradiation. This review come up with an overview of most salient reactions performed under microwave irradiation in the field of drug discovery. Moreover, chemists are preferring to use this reaction rapidly in the academic as well as pharmaceutical laboratory during their drug discovery and making library of compounds. This reaction is much greener using less amount and readily recyclable solvents or sometimes reaction process without solvents and product become much cleaner, often yields are better than the conventional heating. Microwave irradiation is now very robust instrument used in company in the field of drug discovery, due to reduce the reaction time from hour to minute or even second and efficiently creation of compound libraries through combinatorial methodology associated with drug discovery so that new therapeutic agents bring to the market quicker. Hopefully, we will observe in the future the use of microwave irradiation drugs for the patients and this technology will utilize increase in number extensively in the field of medicinal chemistry. As this is an exceedingly rapid evolution area, this review offers significant expertise to the interested readers.

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“…5; 111). 69 The synthesis of anticarcinogenic isoflavones (Fig. 6; 113), 70 the antileukaemic alkaloid, convolutamydine-A (Fig.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

The Impact of Microwave Irradiation Reaction in Medicinal Chemistry: A Review

Pal¹,

Gayen²

2021

Orient. J. Chem

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“…9 An especially productive use of thiazoles has been in antibiotics. [10][11][12][13][14] In fact, there are at least 12 thiazole-containing cephalosporin-type β-lactam antibiotics approved for use by the FDA. Many other important bioactive molecules contain the thiazole group ( Figure 4).…”

Section: Synthesis Of Thiazolesmentioning

confidence: 99%

“…For instance, when thioureas (7) are used instead of thioamides, the 2-aminothiazole 10 can be obtained generally in good yields. 17 Another important variation uses dithiocarbamic acids (8) to condense with α-halocarbonyls to afford 2-sulfanylthiazoles (11). 18 Finally, fully trisubstituted thiazoles (12) can be produced utilizing secondary halides (6, R 2 , R 2 ≠H) and thioamides (9) as precursors.…”

Section: Synthesis Of Thiazolesmentioning

confidence: 99%

6.13 Use of Carbonyl Derivatives for Heterocyclic Synthesis

Schiltz¹

2014

Comprehensive Organic Synthesis II

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“…[32][33][34][35][36] Therefore, AMT with both the sulfur and nitrogen atoms was used as inhibitor on lots of metal surfaces (e.g., copper, bronze, silver, cobalt, and mild steel). [29,33,[37][38][39][40][41][42][43] However, here, we were surprised to find that AMT not only can form insoluble complexes with copper ions, but also can form a kind of new metalorganic gel.…”

Section: Introductionmentioning

confidence: 99%

Antibiofouling Performance of a Metal‐Organic Gel Based on 2‐Amino‐5‐Mercapto‐1,3,4‐Thiadiazole and CuI

Zhang

et al. 2022

Adv Materials Inter

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emission of greenhouse gas because of fouling organisms settled on the submerged surfaces. [6][7][8] Biofouling can also destroy port and fishery infrastructures severely, such as clogging circulation piping. [9] In addition, marine biofouling can cause heavy economic burden. [6] For instance, according to the investigation of A. Abbott et al., [10] the additional expenses on the voyage San Francisco-Yokohama increased by $78 300 (≈77%), and the extra cost of the single voyage on Rotterdam-Calcutta increased by $143 375 (≈58%), which were due to ship's hull fouling. Strategies to prevent biofouling have been developed, including non-coating (electrical, irradiation, sonochemical techniques, surface cleaning, etc.) and coating techniques. [11] Among them, the coating techniques can be broadly divided into biocidal antifouling paints, fouling-release coatings and fouling-resistant coatings. [11][12][13] As an environment-friendly material, hydrogel has been applied in lots of fields, such as tissue engineering, [14,15] drug delivery, [16] cell engineering, [17] shape memory, [18] sensors, and soft robots. [19,20] Studies have proved that certain soft and wet surfaces, such as external layers of dolphins, porpoises, and killer whales in the marine environment, are not fouled by macrofoulers. [21] Inspired by bionics, hydrogel has been studied as an antifouling material. For example, the 3rd generation hydrogel silicone fouling release technology of Hempel has been commercialized. They modified the surface of commercial polydimethylsiloxane (PDMS) matrixes with self-stratifying hydrogelpromoting polymers, which markedly improved the fouling resistance. [22] Kihak Gwon et al. [23] prepared several antibacterial MOF-embedded hydrogels by thiolene photopolymerization between diacrylated PEG (PEG-DA) and 4-arm thiolated PEG (4-arm PEG-SH) under UV irradiation. These MOF-embedded hydrogels were very stable and showed excellent antibacterial activity. As a special kind of hydrogel, metal-organic gels or metallogels (MOGs) are usually made up with metal ions and organic ligands through metal coordination bonds, electrostatic, van der Waals, hydrophobic, hydrogen bonding, and π-π stacking interactions. [24,25] Because of the excellent surface affinity, stimulation response and high specific surface area, MOGs can be used in medicine, environment, biology, sensing, and adsorption. [26][27][28] Nevertheless, until now, the MOGs have not been reported in the marine field for resisting biofouling.2-Amino-5-mercapto-1,3,4-thiadiazole (C 2 H 3 N 3 S 2 , AMT) is white-yellowish powdered crystalline solid at room temperature, which is regarded as a planar, pentaheterocyclic Metal-organic gels or metallogels (MOGs), which usually made up with metal ions and organic ligands, are promising in the area of medicine, environment, and biology. Herein, a new metal-organic gel containing Cu + (Cu-MOG-5) is prepared at room temperature using 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) and CuI. Considering the excellent low surface energy chara...

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Microwave Induced Synthesis and Antibacterial Activity of Cephalosporin Derivatives Using Solid Support

Cited by 13 publications

References 13 publications

The Impact of Microwave Irradiation Reaction in Medicinal Chemistry: A Review

The Impact of Microwave Irradiation Reaction in Medicinal Chemistry: A Review

6.13 Use of Carbonyl Derivatives for Heterocyclic Synthesis

Antibiofouling Performance of a Metal‐Organic Gel Based on 2‐Amino‐5‐Mercapto‐1,3,4‐Thiadiazole and CuI

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