Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

Bandyopadhyay, Debasish; Banik, Bimal K.

doi:10.1016/b978-0-12-800070-0.00019-0

Cited by 9 publications

(3 citation statements)

References 83 publications

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“…We demonstrated indium-induced reactions for the synthesis of diverse compounds under environmentally benign conditions [22]. Most of the indium-mediated reactions as described above produced products with high yields.…”

Section: Resultsmentioning

confidence: 99%

Indium Metal-Induced Reactions: Synthesis of Biologically Active Molecules

Banik

2017

Asian J. Chem.

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INTRODUCTIONIndium metal is highly economical and readily available. Our research group has been conducting indium-mediated useful reactions for the past 20 years. Synthesis of diverse organic molecules in chiral and achiral form is realized by indium-induced reactions very effectively. Most of these reactions are performed in aqueous ethanol. Moreover, indium-mediated reactions can be easily performed under microwave irradiation and ultrasound-mediated methods making these processes are attractive. Illustrative examples are provided here that include various compounds of interests. RESULTS AND DISCUSSIONIndium metal is a versatile reagent in organic synthesis and readily available with extremely low cost. Importantly, this metal is not sensitive in water like most of the other metals. It has been possible to conduct numerous successful reactions with indium-mediated reactions for the preparation of diverse organic compounds. A short summary of reactions that are developed in our laboratory is discussed in this perspective.Synthesis of β β β β β-lactams: Indium metal was used for the preparation of 3-unsubstituted β-lactams by the reaction of an imine with ethylbromoacetate. A variety of imines derived from monocyclic benzene derivatives were successfully employed. In some examples, a mixture of β-lactams and β-amino esters were produced [1]. However, β-amino esters were cyclized to the β-lactams by treatment with Grignard reagent. This method was then successfully applied for the preparation of 3,4-disubs- Indium metal has proven to be extremely useful in our research for the synthesis of diverse organic compounds of significant importance. PERSPECTIVE

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Section: Resultsmentioning

confidence: 99%

Indium Metal-Induced Reactions: Synthesis of Biologically Active Molecules

Banik

2017

Asian J. Chem.

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“…[16][17][18][19] Consequently, heterocyclic compounds have emerged as key components in the synthesis of therapeutics for a wide range of diseases, including cancer, [20] infectious diseases, and neurological disorders. [21][22][23][24][25] Numerous efforts have been made to enhance the urease inhibitory potency and selectivity of existing azole drugs by modifying their structures. [26][27][28] Despite the potential antibacterial and antifungal activities associated with certain tetrazoles, the role of the tetrazole moiety in this pharmacophore has been largely overlooked, with only a few studies addressing it.…”

Section: Introductionmentioning

confidence: 99%

“…The incorporation of nitrogen atoms within the heterocyclic ring imparts unique electronic and steric properties, influencing their interactions with biological macromolecules [16–19] . Consequently, heterocyclic compounds have emerged as key components in the synthesis of therapeutics for a wide range of diseases, including cancer, [20] infectious diseases, and neurological disorders [21–25] . Numerous efforts have been made to enhance the urease inhibitory potency and selectivity of existing azole drugs by modifying their structures [26–28] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of Tetrazole Derivatives with Pyrrole‐2,5‐Dione Moieties as Urease Inhibitors: Exploring Structure‐Activity Relationships and Computational Insights

Muhammed Aziz,

Ali Hassan

2024

ChemistrySelect

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A series of Tetrazole derivatives containing pyrrole‐2,5‐dione groups (5 a–e) were synthesized and comprehensively characterized using HRMS, FT‐IR, and 1H−, 13C‐NMR spectroscopic techniques. These compounds were evaluated for their ability to inhibit urease activity in vitro, demonstrating remarkable inhibitory potential with IC50 values ranging from 4.325±1 to 18.28±1 μM, surpassing the standard thiourea (IC50=17.386±1 μM). Notably, compounds 5 b (IC50=4.325±1 μM), 5 e (IC50=7.411±1 μM), 5 c (IC50=9.313±1 μM), and 5 a (IC50=10.46±1 μM) exhibited notably higher activity compared to the standard thiourea. In our exploration of the structure‐activity relationship (SAR), we investigated the impact of differently substituted aryl rings on inhibitory potential. Our results highlight the crucial role of substituent positioning on the aryl ring, independent of the nature of the substituents. Additionally, computational studies were conducted on all compounds, supporting our experimental findings. Molecular docking simulations revealed a strong correlation between biological evaluation results and computational predictions, affirming the promising inhibitory activity of the compounds.

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Recent Progress on Bimetallic‐Based Spinels as Electrocatalysts for the Oxygen Evolution Reaction

Olowoyo

Kriek

2022

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Among other energy alternatives, such as wind and solar, hydrogen in itself is considered a viable and ideal option due to its zero CO 2 emission, high gravimetric energy density, pollution-free advantages, and independence of weather conditions. [2] However, the traditional production of hydrogen, through steam methane reforming and coal gasification, is by no means feasible in the long term due to its associate carbon footprint. To circumvent the "pitfalls" associated with traditional hydrogen production technologies, electrochemical water splitting, when coupled with carbon-free electricity, offers greater hope.Generally, electrochemical water splitting comprises of two half-reactions: 1) proton reduction, also known as the hydrogen evolution reaction (HER), which occurs at the cathode (Reactions 1 and 3), and 2) water oxidation, also known as the oxygen evolution reaction (OER), which occurs at the anode (Reactions 2 and 4). [3] These half-reactions combine into the overall water-splitting reaction (Reaction 5).

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Microwave-Induced Synthesis of Heterocycles of Medicinal Interests

Cited by 9 publications

References 83 publications

Indium Metal-Induced Reactions: Synthesis of Biologically Active Molecules

Indium Metal-Induced Reactions: Synthesis of Biologically Active Molecules

Synthesis, Characterization, and Evaluation of Tetrazole Derivatives with Pyrrole‐2,5‐Dione Moieties as Urease Inhibitors: Exploring Structure‐Activity Relationships and Computational Insights

Recent Progress on Bimetallic‐Based Spinels as Electrocatalysts for the Oxygen Evolution Reaction

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