Microwave Irradiation for Accelerating the Synthesis of Thioglycosides.

Abstract

Carbohydrates U 0500Microwave Irradiation for Accelerating the Synthesis of Thioglycosides. -A simple and efficient procedure for the synthesis of thioglycosides of type (III), (V),, (IX), and (XI) is described. The results, compared with those obtained for conducting the reactions without microwaves, show similar yields in shorter reaction times. -(EL ASHRY*, E. S. H.; AWAD, L. F.; ABDEL HAMID, H. M.; ATTA, A. I.; Synth.

Synthesis and antiviral activity of new substituted pyrimidine glycosides

“…The residue resulted from evaporation of the filtrate under reduced pressure was purified by recrystallization from absolute ethanol to afford 8a-c in 78-83 yields. 26 [41]. Galactose pentaacetate (12 g, 30.76 mmol) was dissolved in dry dichloromethane (24 mL) and placed in a 250-mL conical flask fitted with a glass stopper.…”

“…On the other hand, nucleoside analogs are structurally, metabolically, and pharmaco-dynamically related agents that have diverse biological actions and therapeutic effects including antiviral [21,22], and antitumor [23,24] activities. Furthermore, the acyclic nucleoside [25][26][27][28], analogues including modifications of both the acyclic glycon and aglycon parts have stimulated extensive research as biological inhibitors [29,30]. The importance of substituted hydroxyl alkyl chain conformation in the interaction of acyclic nucleosides with enzymes has been demonstrated [31].…”

A Journey into Recent Microwave‐Assisted Carbohydrate Chemistry

“…Upon MWI, El Ashry et al [55] efficiently oxidized d-glucose with bromine-water into d-gluconic acid, which was used for conversion into ethyl d-gluconate, First studied was the reaction of GlcA (71) with methanol in the presence of various catalysts to give the 6,3-lactone 73 (scheme 21.23, Table 21.7).…”

Regioselectivity in the glycosylation of 5-(3-chlorobenzo[b]thien-2-yl)-4H-1,2,4-triazole-3-thiol

“…Thus, these compounds serve as useful intermediates for the synthesis of oligosaccharides. [6][7][8][9][10][11][12][13][14] On the other hand, the 1,2,4-triazole nucleus is found in many drug structures such as anastrozole, estazolam, ribavirin, and triazolam. In addition, these compounds show antiseptic, analgesic, and anticonvulsant properties.…”