Microwave power absorption differences between normal and malignant tissue

Joines, William T.; Jirtle, Randy L.; Rafal, Marc D.; Schaefer, Daniel J.

doi:10.1016/0360-3016(80)90223-0

Cited by 104 publications

(54 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…pðr; tÞj t¼T ¼ 0; uðr; tÞj t¼T ¼ 0; pðr m ; tÞ ¼pðr m ; tÞ: (5) Unlike the approach proposed by Xin et al, 20 this algorithm is based on a full-wave solution to the acoustic wave equation for heterogeneous media, and can therefore compensate for scattering due to variations in c 0 ðrÞ and ρ 0 ðrÞ within the skull. Because the fast Fourier transform (FFT) algorithm is employed to compute the spatial derivatives in the k-space pseudospectral method, 29 its computational efficiency is superior to competing methods such as finite-difference time-domain methods.…”

Section: Image Reconstruction Based On Time-reversalmentioning

confidence: 99%

“…From knowledge of these data, a reconstruction algorithm is employed to estimate the initial induced pressure distribution or, equivalently if the Grueneisen parameter is known, 2,4 the absorbed optical energy distribution within the tissue. Because optical contrast is dependent on hemoglobin concentration and related to the molecular constitution of tissue, PAT can reveal the pathological condition of the tissue, 5,6 and therefore facilitate a wide-range of diagnostic tasks. [7][8][9][10][11] Transcranial brain imaging represents an important application that may benefit significantly by the development of PAT methods.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang

2012

J. Biomed. Opt

View full text Add to dashboard Cite

Abstract. A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.

show abstract

Section: Image Reconstruction Based On Time-reversalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang

2012

J. Biomed. Opt

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4] To employ this contrast mechanism, thermoacoustic tomography ͑TAT͒, in which the thermoacoustic signals from a tissue sample are collected to map the distribution of the radiation absorption within the sample, has been developed to image biological tissue. [5][6][7][8][9] TAT, which is also referred to as photoacoustic or optoacoustic tomography ͑depending on the type of radiation used͒, combines good imaging resolution with good imaging contrast.…”

Section: Introductionmentioning

confidence: 99%

Reconstructions in limited‐view thermoacoustic tomography

et al. 2004

View full text Add to dashboard Cite

The limited-view problem is studied for thermoacoustic tomography, which is also referred to as photoacoustic or optoacoustic tomography depending on the type of radiation for the induction of acoustic waves. We define a ''detection region,'' within which all points have sufficient detection views. It is explained analytically and shown numerically that the boundaries of any objects inside this region can be recovered stably. Otherwise some sharp details become blurred. One can identify in advance the parts of the boundaries that will be affected if the detection view is insufficient. If the detector scans along a circle in a two-dimensional case, acquiring a sufficient view might require covering more than a -, or less than a -arc of the trajectory depending on the position of the object. Similar results hold in a three-dimensional case. In order to support our theoretical conclusions, three types of reconstruction methods are utilized: a filtered backprojection ͑FBP͒ approximate inversion, which is shown to work well for limited-view data, a local-tomography-type reconstruction that emphasizes sharp details ͑e.g., the boundaries of inclusions͒, and an iterative algebraic truncated conjugate gradient algorithm used in conjunction with FBP. Computations are conducted for both numerically simulated and experimental data. The reconstructions confirm our theoretical predictions.

show abstract

“…For example, the absorption coefficient in cancerous breast tissue is two to five times greater than that in normal breast tissue, due to the increment of water and sodium bounded within malignant cells. [1][2][3] This large difference makes it promising to use microwave-induced thermoacoustic tomography to detect breast cancers.…”

Section: Introductionmentioning

confidence: 99%

Microwave‐induced thermoacoustic tomography: Reconstruction by synthetic aperture

Feng

et al. 2001

Medical Physics

View full text Add to dashboard Cite

We have applied the synthetic-aperture method to linear-scanning microwave-induced thermoacoustic tomography in biological tissues. A nonfocused ultrasonic transducer was used to receive thermoacoustic signals, to which the delay-and-sum algorithm was applied for image reconstruction. We greatly improved the lateral resolution of images and acquired a clear view of the circular boundaries of buried cylindrical objects, which could not be obtained in conventional linearscanning microwave-induced thermoacoustic tomography based on focused transducers. Two microwave sources, which had frequencies of 9 and 3 GHz, respectively, were used in the experiments for comparison. The 3 GHz system had a much larger imaging depth but a lower signal-noise ratio than the 9 GHz system in near-surface imaging.

show abstract

Microwave power absorption differences between normal and malignant tissue

Cited by 104 publications

References 20 publications

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Reconstructions in limited‐view thermoacoustic tomography

Microwave‐induced thermoacoustic tomography: Reconstruction by synthetic aperture

Contact Info

Product

Resources

About