Microwave preparation of osmium clusters with anticancer activity; rapid syntheses of Os6(CO)18, Os3(CO)10(acetonitrile)2, and Os3(μ-H)(μ-OH)(CO)10

Jung, Jade Y.; Kempe, David K.; Loh, Li-Hsing J.; Shoultz, Sara E.; Powell, Gregory L.

doi:10.1016/j.jorganchem.2011.12.001

Cited by 8 publications

(2 citation statements)

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“…In order to obtain a significant quantity of III for crystal growing attempts, we sought a higher yield method of preparing this osmole complex. We turned to microwave heating since it had been shown to offer improved efficiency for the preparation of certain other osmium carbonyl complexes (Johnson & Powell, 2008;Leadbeater & Shoemaker, 2008;Jung et al, 2012;Pyper et al, 2013).…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of [μ-1κ² C ¹,C ⁴:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)

et al. 2018

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of [μ-1κ² C ¹,C ⁴:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)

et al. 2018

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“…Microwave irradiation offers several unique advantages like enhanced yields, reproducibility, cleaner reactions, and being used as an alternative thermal energy source to conventional heating [10,11]. It has been applied to a wide range of reactions like cycloaddition, organometallic reactions, and nanoparticle synthesis [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies

2014

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An efficient one-pot synthesis of xanthene and chromene derivatives by three-component reactions of aryl aldehydes, cyclic 1,3-diketones, and 2-naphthol/ 4-hydroxy coumarin catalyzed by ionic liquid (IL) [bmim] [PF 6 ] under microwave irradiation is described. The present scheme provides several advantages such as short reaction time, mild reaction conditions, good yields, convenient operation, and reuse of IL. In vitro antioxidant activity was evaluated for the synthesized compounds by DPPH method. Compounds 6a, 6h, 6c, 6b, 4k, and 4a showed the highest antioxidant potency.

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Cytotoxic Triosmium Carbonyl Clusters: A Structure–Activity Relationship Study

et al. 2014

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A structure-activity relationship (SAR) study of the triosmium carbonyl cluster Os3 (CO)10 (NCCH3 )2 was carried out with a series of clusters of the general formula Os3 (CO)12-n Ln , cationic osmium clusters and a hemi-labile maltolato-Os cluster. The SAR results showed that good solubility in DMSO and at least one vacant site are required for cytotoxicity. In vitro evaluation of these new compounds showed that some are selectively active against estrogen receptor (ER)-independent MDA-MB-231 breast cancer cell lines relative to ER-dependent MCF-7 breast cancer cells, suggesting that the compounds have a different biological target specific to MDA-MB-231 cells. In particular, the maltolato cluster exhibits strong antiproliferative activity, with an IC50 value of 3 μM after only 24 h incubation. Additionally, biochemical assays conducted with the cationic cluster show that it induces apoptosis, although a biological target has not yet been identified. Further research to establish the molecular targets of these compounds and to develop improved organometallic clusters as potential breast cancer therapeutics is underway.

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Microwave preparation of osmium clusters with anticancer activity; rapid syntheses of Os6(CO)18, Os3(CO)10(acetonitrile)2, and Os3(μ-H)(μ-OH)(CO)10

Cited by 8 publications

References 25 publications

Crystal structure of [μ-1κ² C ¹,C ⁴:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)

Crystal structure of [μ-1κ² C ¹,C ⁴:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)

Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies

Cytotoxic Triosmium Carbonyl Clusters: A Structure–Activity Relationship Study

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Microwave preparation of osmium clusters with anticancer activity; rapid syntheses of Os6(CO)18, Os3(CO)10(acetonitrile)2, and Os3(μ-H)(μ-OH)(CO)10

Cited by 8 publications

References 25 publications

Crystal structure of [μ-1κ2 C 1,C 4:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)

Crystal structure of [μ-1κ2 C 1,C 4:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)

Microwave-assisted clean synthesis of xanthenes and chromenes in [bmim][PF6] and their antioxidant studies

Cytotoxic Triosmium Carbonyl Clusters: A Structure–Activity Relationship Study

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Product

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Crystal structure of [μ-1κ² C ¹,C ⁴:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)

Crystal structure of [μ-1κ² C ¹,C ⁴:2(1,2,3,4-η)-1,2,3,4-tetraphenylbuta-1,3-diene-1,4-diyl]bis(tricarbonylosmium)(Os—Os)