Microwave thermochemotherapy in the treatment of the bladder carcinoma-electromagnetic and dielectric studies-clinical protocol

Dietsch, A.; Camart, J.C.; Sozański, Jarosław; Prevost, B.; Mauroy, Brigitte; Chive, M.

doi:10.1109/10.841335

Cited by 18 publications

(15 citation statements)

References 14 publications

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“…The composition of polyacrylamide-based materials, in particular, can be adjusted to mimic the electrical and thermal properties of various types of human tissue [1][2][3] . As a result, these materials have been used extensively to evaluate radiofrequency (RF) and microwave applicators for hyperthermia and thermal therapy [4][5][6][7][8][9][10][11][12][13][14][15][16] , to validate numerical simulations of RF and microwave-based hyperthermia treatments 13,[17][18][19] and to evaluate the use of various thermometry techniques in RF and microwave hyperthermia [20][21][22][23][24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Measurement of the thermal conductivity of polyacrylamide tissue-equivalent material

Davidson

Sherar

2003

International Journal of Hyperthermia

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The purpose of this work was to measure the thermal conductivity of polyacrylamide (PAG) and compare it with previously reported values. Polyacrylamide phantoms play an important role in the development of hyperthermia and high-temperature thermal therapies based on electromagnetic (EM) radiation by providing a material that mimics the electrical and thermal properties of human tissue. The thermal properties of PAG have, up until now, not been thoroughly investigated and at least two significantly different values have been published. In this study, the thermal conductivity of polyacrylamide was measured from the steady state temperature drop across samples exposed to a known heat flux. The measured conductivity was 0.56 +/- 0.047 W m(-1) degrees C(-1). To validate the correct set of thermal properties for polyacrylamide, simple heating experiments were performed in a PAG phantom and then simulated using a finite element numerical model that incorporated the measured thermal conductivity along with literature values for specific heat and density. Temperature predictions from the model agreed with average temperatures measured in the phantom to within 1 SD of the measured temperatures.

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Section: Introductionmentioning

confidence: 99%

Measurement of the thermal conductivity of polyacrylamide tissue-equivalent material

Davidson

Sherar

2003

International Journal of Hyperthermia

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“…Third, the fluidic content of the targets is water and urine. At 3.5 GHz, the conductivity of urine is somewhat higher (σ u =4.91 S/m (Dietsch et al 2000)) than water (σ w =2.9 S/m, see figure 9). From equation (6), it is seen that the weighting function is proportional to the conductivity, making the urine volume a stronger radiometric source than the water volume.…”

Section: Discussionmentioning

confidence: 97%

Radiometric temperature reading of a hot ellipsoidal object inside the oral cavity by a shielded microwave antenna put flush to the cheek

Klemetsen

Jacobsen²,

Birkelund³

2012

Phys. Med. Biol.

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Abstract.A new scheme for detection of vesicoureteral reflux (VUR) in children has recently been proposed in the literature. The idea is to warm bladder urine via microwave exposure to at least fever temperatures, and observe potential urine reflux from the bladder back to the kidneys by medical radiometry. As a preliminary step towards realization of this detection device, we present non invasive temperature monitoring by use of microwave radiometry in adults to observe temperature dynamics in vivo of a water filled balloon placed within the oral cavity. The relevance of the approach with respect to detection of VUR in children is motivated by comparing the oral cavity and cheek tissue with axial CT images of young children in the bladder region. Both anatomical locations reveal a triple-layered tissue structure consisting of skin-fat-muscle with a total thickness of about 8-10 mm. In order to mimic variations in urine temperature, the target balloon was flushed with water coupled to a heat exchanger, that was moved between waterbaths of different temperature, to induce measurable temperature gradients.The applied radiometer has a center frequency of 3.5 GHz and provides a sensitivity (accuracy) of 0.03 o C for a data acquisition time of 2 secs. Three different scenarios were tested and included observation through the cheek tissue with and without an intervening water bolus compartment present. In all cases, radiometric readings observed over a time span of 900 secs were shown to be highly correlated (R∼0.93) with in situ temperatures obtained by fiberoptic probes. 71Radiometric temperature reading of a hot object inside the oral cavity 2

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“…T HE TECHNIQUE of the microwave heating have been applied to medical treatments for a wide range of diseases, including cancer, arrhythmia, and prostatomegaly [1]- [9]. These medical applications are based on the thermal effect of the biological tissue exposed to microwave energy.…”

Section: Introductionmentioning

confidence: 99%

The Development of Forceps-Type Microwave Tissue Coagulator for Surgical Operation

Endo

Saito

Ito

2015

IEEE Trans. Microwave Theory Techn.

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In this paper, a new type of surgical device for the coagulation and scission of biological tissues, such as blood vessels, using microwave energy is proposed. In addition, the effectiveness of the device for tissue coagulation is evaluated using a numerical analysis and an ex vivo experiment with swine liver tissue. In the numerical analysis, the coagulating capability of the device is evaluated by calculating the temperature distribution inside of the tissue grasped with the device. Microwave energy absorbed by the grasped tissue is used as a heat source for the bioheat transfer equation. In the ex vivo experiment, a prototype of the proposed device is used. The results of these investigations indicate that the proposed device has sufficient coagulating capability of the biological tissue. Moreover, for evaluating the effectiveness of the proposed device in a more realistic condition, an in vivo experiment with the swine tissue has been conducted. In this experiment, venous hemorrhage at the surgical site is stopped using the prototype. As a result, the effectiveness of the proposed device has been confirmed by a surgeon.Index Terms-Finite difference time domain (FDTD), medical applications, microwave heating, surgical device.

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Microwave thermochemotherapy in the treatment of the bladder carcinoma-electromagnetic and dielectric studies-clinical protocol

Cited by 18 publications

References 14 publications

Measurement of the thermal conductivity of polyacrylamide tissue-equivalent material

Measurement of the thermal conductivity of polyacrylamide tissue-equivalent material

Radiometric temperature reading of a hot ellipsoidal object inside the oral cavity by a shielded microwave antenna put flush to the cheek

The Development of Forceps-Type Microwave Tissue Coagulator for Surgical Operation

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