Cold limb injury remains a serious and widespread condition both in countries with a cold climate and in regions located close to the equator, but having high-altitude territories. There is no medical equipment for the treatment of this condition. One of the ways to solve this problem is the use of microwave radiation at an early stage, which penetrates deep into the cooled volume and, accordingly, can accelerate the activation of internal vessels. The technical implementation of this approach involves the selection of the appropriate frequency and power of radiation, as well as the creation of a microwave chamber in which it is possible to ensure a sufficiently uniform heating of the entire volume of the frostbitten limb. The results of modeling the distributions of electromagnetic and thermal fields in the volume of the heated limb at microwave frequencies allowed for medical applications are presented.