Micrurus surinamensis Peruvian snake venom: Cytotoxic activity and purification of a C-type lectin protein (Ms-CTL) highly toxic to cardiomyoblast-derived H9c2 cells

Rincon-Filho, Silvio; Souza, Dayane Lorena Naves de; Lopes-de-Souza, Letícia; Silvano-de-Oliveira, Jamil; Bonilla-Ferreyra, Cesar; Costal-Oliveira, Fernanda; Guerra-Duarte, Clara; Chávez-Olortégui, Carlos

doi:10.1016/j.ijbiomac.2020.08.033

Cited by 5 publications

(2 citation statements)

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“…The first group, which is predominant, is thrombin-like enzymes, and it stimulates the blood clotting process and forms fibrin by cleaving the Aα and/or Bβ chains of fibrinogen [7,26,30,41]. L-amino acid oxidases (LAAO): L-amino acid oxidases (LAAOs) are flavoproteins found in Elapidae and Viperidae, but especially in Crotaline [11,32,42]. These enzymes represent a variety of biological activities in the victim such as cytotoxicity, myotoxicity, and edema, which induce clinical symptoms of envenomation [11,23,40,43].…”

Section: Serine Proteases (Svsp)mentioning

confidence: 99%

“…It has a wide range of biological activities like ion channels blockage especially voltage-gated potassium channels which may lead to anticoagulation, fibrinolysis, and inflammation [6,53]. C-type lectins (CTL): C-type lectins are non-enzymatic proteins and Ca2+ dependent carbohydrate proteins [42][43][44][45][46][47][48][49]. These family of proteins are found in many different tissue types and are primarily involved in adherence and immunity and signalling related to inflammation [18].…”

Section: Serine Proteases (Svsp)mentioning

confidence: 99%

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A Review on Anti-Thrombotic Agents Derived from Snake Venom Protein

Alharbi¹,

Alabbas²,

Sumnudi³

et al. 2022

PJMHS

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Background: Snakes have always attracted scientists and it caused awe and fear because of the harmful strength of its toxins and the components of various toxins from one snake to another. In 2017, the World Health Organization (WHO) listed snake venom as a neglected high-priority disease, with snakes causing up to 2.7 million venomous bites, nearly 100,000 victims, and nearly three times the number of human disabilities. Objective: i- Snake venom background and therapeutics properties ii- The effects of snake bite iii- the mechanism of haemostasis iv- Types of antithrombotic agents derived from snake venom proteins. Conclusion: Snake venoms are a group of diverse compounds and because of their diversity, they lead to many effects that have different effects on the body, causing an imbalance and mastery of the victim. Just as these components have toxic effects, they have clinical and therapeutic effects. The previous research shown the clinical benefits of snake venom, such as the drug captopril used to treat high blood pressure, And the defibrase used for the prevention of thrombotic disease. Therefore, snake venom components need several studies. They are still unidentified due to the difficulty of obtaining them adequate. Keywords: Snake venoms, antithrombotic, haemostasis, venom proteins.

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