2014
DOI: 10.1089/omi.2013.0157
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Mid-ATR-FTIR Spectroscopic Profiling of HIV/AIDS Sera for Novel Systems Diagnostics in Global Health

Abstract: Global health, whether in developed or developing countries, is in need of robust systems diagnostics for major diseases, such as HIV/AIDS, impacting the world populations.

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Cited by 69 publications
(37 citation statements)
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“…Omics biotechnologies such as genomics, proteomics, and metabolomics allow us to repurpose drugs or examine the system scale impacts of molecular perturbations, be they induced by drugs, nutrition, xenobiotics, or changes in the environmental stressors (Dandara et al, 2014;Gong et al, 2014;Kale et al, 2015;Kato et al, 2015;McCabe et al, 2015;Mounayar et al, 2014;Sahu et al, 2014;Sitole et al, 2014;Zheng et al, 2014). Based on the combined microarray, proteomics, and in silico data, a signaling pathway for L-mentholinduced apoptosis is being presented for the first time here.…”
Section: Discussionmentioning
confidence: 99%
“…Omics biotechnologies such as genomics, proteomics, and metabolomics allow us to repurpose drugs or examine the system scale impacts of molecular perturbations, be they induced by drugs, nutrition, xenobiotics, or changes in the environmental stressors (Dandara et al, 2014;Gong et al, 2014;Kale et al, 2015;Kato et al, 2015;McCabe et al, 2015;Mounayar et al, 2014;Sahu et al, 2014;Sitole et al, 2014;Zheng et al, 2014). Based on the combined microarray, proteomics, and in silico data, a signaling pathway for L-mentholinduced apoptosis is being presented for the first time here.…”
Section: Discussionmentioning
confidence: 99%
“…It also provides the conformation structure of molecules and specific fingerprint-type information. FT-IR and Raman spectroscopy are multipurpose techniques that offer advantages in simplicity, rapidity, low cost and minimal sample preparation [8]. Spectroscopic analysis allows for objective classification on a molecular level [7].…”
Section: Introductionmentioning
confidence: 99%
“…Similarly, biomolecules exhibit responses to different wavelengths of light, the resulting Fourier transform infrared (FT-IR) spectroscopy can be thought of as the sample "fingerprint". Therefore, they have been widely used on diagnosis of dengue infection [9], hepatitis B virus [9], HIV/AIDS [8], and so on. FT-IR and Raman spectroscopy are multipurpose techniques that offer advantages in simplicity, rapidity, low cost and minimal sample preparation [8].…”
Section: Introductionmentioning
confidence: 99%
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“…Likewise, FT‐IR spectroscopy has been successfully used to investigate spectral variations linked to different molecular constituents and to detect diseased states in different tissues and cells . Segregation of HIV‐infected patients vs. control by applying FT‐IR technology has also been analyzed in a few studies .…”
Section: Introductionmentioning
confidence: 99%