In this paper, we propose a novel type of hollow-core anti-resonance fiber (HC-ARF). The cladding region of this fiber is formed by a combination of nested tubes and U-shaped tubes, and the centrally symmetric arrangement significantly reduces sensitivity to polarization. The influence of parameters on the performance of the designed HC-ARF LMA is analyzed by a finite element algorithm. The simulation results demonstrate that the designed structure achieves a large mode area of 3180 µm2, bending loss of 2 × 10−2 dB/km, and confinement loss of 5 × 10−3 dB/km at a wavelength of 1064 nm. Similarly, at a wavelength of 1550 nm, the large mode area, bending loss, and confinement loss are 3180 µm2, 1.4 × 10−2 dB/km, and 4 × 10−2 dB/km, respectively. These results indicate unprecedentedly large mode areas and ultra-low losses compared to previous studies. Within the bending radius under consideration, the bending loss remains below 1.35 × 10−2 dB/km. Furthermore, by increasing the fiber radius, the large mode area can reach an extraordinary 6250 µm2. The proposed device exhibits excellent mode area and outstanding polarization insensitivity, along with favorable bending performance. We believe that the designed fiber holds promising applications in high-power miniaturized fiber lasers, fiber amplifiers, and various high-power fiber communication systems, and it can be applied in sensors that require polarization insensitivity and better bending performance.