Mid-Infrared Photoacoustic Detection of Glucose in Human Skin: Towards Non-Invasive Diagnostics

Kottmann, Jonas; Rey, Julien; Sigrist, Markus W.

doi:10.3390/s16101663

Cited by 95 publications

(60 citation statements)

References 33 publications

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“…Subsequently, a PAS setup was presented employing two EC-QCLs at fixed emission wavelengths of 1080 and 1180 cm À1 . 221 An oral glucose tolerance test was performed with a healthy volunteer. Without applying chemometric methods, the computed signal ratio of the two wavelengths reasonably follows glucose levels that were simultaneously determined by a commercial glucometer.…”

Section: Analysis Of Bodily Fluidsmentioning

confidence: 99%

Quantum cascade lasers (QCLs) in biomedical spectroscopy

2017

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Quantum cascade lasers (QCL) are the first room temperature semiconductor laser source for the mid-IR spectral region, triggering substantial development for the advancement of mid-IR spectroscopy. Mid-IR spectroscopy in general provides rapid, label-free and objective analysis, particularly important in the field of biomedical analysis. Due to their unique properties, QCLs offer new possibilities for development of analytical methods to enable quantification of clinically relevant concentration levels and to support medical diagnostics. Compared to FTIR spectroscopy, novel and elaborated measurement techniques can be implemented that allow miniaturized and portable instrumentation. This review illustrates the characteristics of QCLs with a particular focus on their benefits for biomedical analysis. Recent applications of QCL-based spectroscopy for analysis of a variety of clinically relevant samples including breath, urine, blood, interstitial fluid, and biopsy samples are summarized. Further potential for technical advancements is discussed in combination with future prospects for employment of QCL-based devices in routine and point-of-care diagnostics.

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Section: Analysis Of Bodily Fluidsmentioning

confidence: 99%

Quantum cascade lasers (QCLs) in biomedical spectroscopy

2017

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“…Photoacoustic spectroscopy is an optical detection method widely used for trace gas analysis. Transducers such as microphones [4][5][6], cantilevers [7][8][9][10], or piezoelectric elements [11][12][13] were used to detect acoustic waves and convert them into mechanical or electrical signals. As a significant variant of PAS, quartz-enhanced photoacoustic spectroscopy (QEPAS) has been boomingly developed in the past decades [14,15].…”

Section: Introductionmentioning

confidence: 99%

Quartz-Enhanced Photothermal-Acoustic Spectroscopy for Trace Gas Analysis

et al. 2019

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A crystal quartz tuning fork (QTF) was used as a detector to collect and amplify laser-induced photoacoustic and photothermal waves simultaneously for trace chemical analysis. A wavelength modulation technique was applied to the proposed quartz-enhanced photothermal-acoustic spectroscopy (QEPTAS) to improve the detection signal-to-noise ratio. The QTF detector was exposed to the illumination of a near-infrared distributed feedback laser at distances of 1 m and 2 m to evaluate the QEPTAS sensor performance. The QEPTAS sensor performance was determined by detecting water vapor in ambient air using a near-infrared distributed feedback laser with a power of ~10 mW and a wavelength of 1.39 μm. With an optimized modulation depth of 0.47 cm−1, the normalized noise equivalent absorption (NNEA) coefficients of 8.4 × 10−7 W·cm−1·Hz−1/2 and 3.7 × 10−6 W·cm−1·Hz−1/2 were achieved for a distance of 1 m and 2 m, respectively. The developed QEPTAS technique reduces the requirements for laser beam quality, resulting in a simple but robust sensor structure and demonstrates the ability of remote sensing of gas concentrations.

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“…Thus, photoacoustic based glucose measurements are not influenced by the interference effect of the scattering components. Glucose sensors based on this technique have demonstrated promising results, but are not yet commercially available [78][79][80].…”

Section: Scattering Of Light By Blood Components and Tissuementioning

confidence: 99%

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

Shokrekhodaei

Quinones

2020

Sensors

157

109

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Annual deaths in the U.S. attributed to diabetes are expected to increase from 280,210 in 2015 to 385,840 in 2030. The increase in the number of people affected by diabetes has made it one of the major public health challenges around the world. Better management of diabetes has the potential to decrease yearly medical costs and deaths associated with the disease. Non-invasive methods are in high demand to take the place of the traditional finger prick method as they can facilitate continuous glucose monitoring. Research groups have been trying for decades to develop functional commercial non-invasive glucose measurement devices. The challenges associated with non-invasive glucose monitoring are the many factors that contribute to inaccurate readings. We identify and address the experimental and physiological challenges and provide recommendations to pave the way for a systematic pathway to a solution. We have reviewed and categorized non-invasive glucose measurement methods based on: (1) the intrinsic properties of glucose, (2) blood/tissue properties and (3) breath acetone analysis. This approach highlights potential critical commonalities among the challenges that act as barriers to future progress. The focus here is on the pertinent physiological aspects, remaining challenges, recent advancements and the sensors that have reached acceptable clinical accuracy.

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Mid-Infrared Photoacoustic Detection of Glucose in Human Skin: Towards Non-Invasive Diagnostics

Cited by 95 publications

References 33 publications

Quantum cascade lasers (QCLs) in biomedical spectroscopy

Quantum cascade lasers (QCLs) in biomedical spectroscopy

Quartz-Enhanced Photothermal-Acoustic Spectroscopy for Trace Gas Analysis

Review of Non-Invasive Glucose Sensing Techniques: Optical, Electrical and Breath Acetone

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