Mid‐infrared spectroscopy and multivariate curve resolution for analyzing human adipose tissue triacylglycerols

Lundbom, Jesper; Kolehmainen, Marjukka; Pulkkinen, Leena; Soininen, Pasi; Tiainen, Mika; Schwab, Ursula; Uusitupa, Matti; Tammi, Markku

doi:10.1002/ejlt.201000330

Cited by 2 publications

(2 citation statements)

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“…It has been shown that methylene-interrupted double bonds in polyunsaturated fatty acids give rise to a different absorption pattern than the isolated double bonds in monounsaturated fatty acids in the FT-IR spectra. 67 It has also been claimed that the position of the double bond system relative to the carbonyl group (Δ-position) and the methyl end (ω-position) in polyunsaturated fatty acids has some importance for the IR spectra of polyunsaturated fatty acids. 26…”

Section: Resultsmentioning

confidence: 99%

Determination of Omega-3 Fatty Acids in Fish Oil Supplements Using Vibrational Spectroscopy and Chemometric Methods

2014

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The potential of Fourier transform infrared (FT-IR), near-infrared (NIR), and Raman spectroscopic techniques combined with partial least squares (PLS) regression (PLSR) to predict concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and total omega-3 fatty acids (n-3 FAs) in fish oil supplements was investigated. FT-IR spectroscopy predicted EPA (coefficient of determination (R(2)) of 0.994, standard error of cross-validation (SECV) of 2.90%, and standard error of prediction (SEP) of 2.49%) and DHA (R(2) = 0.983, SECV = 2.89%, and SEP = 2.55%) with six to seven PLS factors, whereas a simpler PLS model with two factors was obtained for total n-3 FAs (R(2) = 0.985, SECV = 2.73%, and SEP = 2.75%). Selected regions in the NIR spectra gave models with good performances and predicted EPA (R(2) = 0.979, SECV = 2.43%, and SEP = 3.11%) and DHA (R(2) = 0.972, SECV = 2.34%, and SEP = 2.60%) with four to six PLS factors. Both the whole and selected NIR regions gave simple models (two PLS factors) with similar results (R(2) = 0.997, SECV = 2.18%, and SEP = 1.60%) for total n-3 FAs. The whole and selected regions of Raman spectra provided models with comparable results and predicted EPA (R(2) = 0.977, SECV = 3.18%, and SEP = 2.73%) and DHA (R(2) = 0.966, SECV = 3.31%, and SEP = 2.56%) with seven to eight PLS factors, whereas a simpler model (three PLS factors) with R(2) = 0.993, SECV = 2.82%, and SEP = 3.27% was obtained for total n-3 FAs. The results demonstrated that FT-IR, NIR, and Raman spectroscopy combined with PLSR can be used as simple, fast, and nondestructive methods for quantitative analysis of EPA, DHA, and total n-3 FAs. FT-IR and NIR spectroscopy, in particular, have the potential to be applied in process industries during production of fish oil supplements.

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Section: Resultsmentioning

confidence: 99%

Determination of Omega-3 Fatty Acids in Fish Oil Supplements Using Vibrational Spectroscopy and Chemometric Methods

2014

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“…The underlying causes of the yellowish hue that defines the xanthodermatoses refer to the chemical structures of the accumulating substances within the skin or surrounding tissues. The most common culprits include lipids (cholesterol and triglycerides), elastin, and bilirubin (Table ). Exogenous sources of yellow pigment include yellow dyes (including hennas) and metal salts.…”

Section: Introductionmentioning

confidence: 99%

Fifty shades of yellow: a review of the xanthodermatoses

2015

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The xanthodermatoses consist of a heterogeneous group of cutaneous disorders characterized by the macroscopic yellow hue seen on examination. This hue is attributable to the chemical structure of the accumulating substances within the skin or surrounding tissues. The most common culprits are lipids (cholesterol and triglycerides), elastin, and bilirubin. Exogenous sources of yellow pigment include yellow dyes (including hennas) and metal salts. This article will focus on recognition of these entities, classified in terms of morphology and the site of initial eruption, in order to support the recognition and diagnosis of these widely variable conditions.

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Mid‐infrared spectroscopy and multivariate curve resolution for analyzing human adipose tissue triacylglycerols

Cited by 2 publications

References 32 publications

Determination of Omega-3 Fatty Acids in Fish Oil Supplements Using Vibrational Spectroscopy and Chemometric Methods

Determination of Omega-3 Fatty Acids in Fish Oil Supplements Using Vibrational Spectroscopy and Chemometric Methods

Fifty shades of yellow: a review of the xanthodermatoses

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