A systematic interdisciplinary approach based on the socio-ecological model of the Vienna school has been adopted to achieve a more nuanced and multifaceted understanding of the ancient metropolis of Pergamon (western Anatolia) and its micro-region. The city of Pergamon ranks among the ‘guiding fossils’ of urban culture in antiquity. We describe how the socio-ecological model is subject to adaptation and discussion to fit the needs and circumstances of archaeology. In focussing on geomorphodynamics, we use several approaches to conceptualise and model selected aspects of human-environment interactions, integrating data from physical geography, archaeology, building archaeology (Bauforschung) and ancient history. The model includes several dimensions of the social metabolism of Pergamon, first and foremost the carrying capacity of the environment and demographics, comprising population increase and labour as an active investment in nature. Geomorphodynamics are regarded as major ‘events’ in the model, related to the social metabolism (e.g. increased erosion/deposition in the micro-region in relation to urban sprawl). With the social-ecological model, it is possible – and becomes imperative – to include the perception and representation of human-environment interactions manifested in, for example, administrative patterns and religious practices or architecture and built infrastructure (such as terraces, riverbank stabilisation, substraction terraces and substraction bridges). Geomorphodynamics also involve various aspects of the perception of the environment, though these are not recorded in ancient texts on Pergamon known to date. Concurrently, the importance of the model in organising, structuring, and communicating interdisciplinary collaboration and discourse is highlighted.