Midbrain substrates of audiogenic seizures in rats

García-Cairasco, Norberto; Terra, Vera Cristina; Doretto, Maria Carolina

doi:10.1016/0166-4328(93)90090-d

Cited by 80 publications

(37 citation statements)

References 61 publications

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“…For the evaluation of audiogenic seizures (AS) in Wistar rats, an audiogenic severity index (SI), including a graded linear scale with a range of severity from SI = 0 (resistant rats) to SI = 1.0 (maximum, susceptible rats), was calculated (30). In order to determine the audiogenic susceptibility of the animals, three acoustic stimulations were performed before the beginning of the experimental protocol.…”

Section: Behavioral Evaluation Of Seizure Activitymentioning

confidence: 99%

“…The behavioral expression of audiogenic seizures, a model of genetically dependent generalized tonic-clonic seizures, seems to depend almost exclusively on brainstem substrates (29,30). Among other mechanisms, inferior colliculus NMDA neurotransmission plays a critical role in the expression of AS (47).…”

Section: L-noargmentioning

confidence: 99%

“…Subconvulsant PILO doses can be used in order to test the blocking effect of NOS on limbic seizure facilitation (9). Audiogenic genetically epilepsy-prone rats (GEPR-3s), Wistar and Sprague-Dawley resistant rats can be used to test seizure increase or de novo appearance after the treatments, whereas GEPR-3s and susceptible Wistar animals can be used to test the reduction in audiogenic seizure, which may suggest an involvement of NO in generalized tonic-clonic seizures (29,30). The seizure models currently used have common and distinct mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models

Del‐Bel

Oliveira

et al. 1997

Braz J Med Biol Res

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The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor N G -nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic components of PTZinduced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitorspecific interactions with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizure.

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Section: Behavioral Evaluation Of Seizure Activitymentioning

confidence: 99%

Section: L-noargmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models

Del‐Bel

Oliveira

et al. 1997

Braz J Med Biol Res

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“…The primary ictogenic zone of audiogenic seizures locates in the inferior colliculus (IC), the major auditory processing center of the brainstem [13][14][15]. In rats with audiogenic epilepsy, this brainstem nucleus exhibits intrinsic epileptogenicity as a result of local deficit in GABAergic inhibition [16].…”

Section: Introductionmentioning

confidence: 99%

Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features

Vinogradova

2017

Epilepsy & Behavior

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“…The central nucleus of the inferior colliculus (CNIC), in particular, has been proposed to be involved in AGS initiation (Willott and Lu, 1980) while the external cortex (ECIC), which receives a dense projection from the ipsilateral CNIC (Coleman and Clerici, 1987), is implicated in the propagation of the seizures (Willott and Lu, 1980;Chakravarty and Faingold, 1996). In several genetic models of AGS, the ECIC mediates the seizure output pathway in the neuronal network for AGS (Le Gal La Salle and Naquet, 1990;McCown et al, 1984) through its connections with the superior colliculus (SC) (Van Buskirk, 1983;Garcia-Cairasco et al, 1993). The mammalian SC is a laminated, midbrain structure that can be functionally divided into superficial and deep laminae (for review, see Stein and Meredith, 1993).…”

Section: Introductionmentioning

confidence: 99%

Morphologic and neurochemical alterations in the superior colliculus of the genetically epilepsy-prone hamster (GPG/Vall)

et al. 2007

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SummaryThe GPG/Vall hamster is an animal model that exhibits seizures in response to sound stimulation. Since the superior colliculus (SC) is implicated in the neuronal network of audiogenic seizures (AGS) in other forms of AGS, this study evaluated seizure-related anatomical or neurochemical abnormalities in the SC of the GPG/Vall hamster. This involved calbindin (CB) and parvalbumin (PV) immunohistochemistry, densitometric analysis and high performance liquid chromatography in the superficial and deep layers of the SC in control and epileptic animals. Compared to control animals, a reduction in SC volume and a hypertrophy of neurons located in the deep layers of the SC were observed in the epileptic hamster. Although, analysis of CB-immunohistochemistry in the superficial layers did not show differences between groups, analysis of PV-immunostaining in the deep SC revealed an increase in the mean gray level within immunostained neurons as well as a decreased immunostained neuropil in the GPG/Vall hamster as compared to control animals. These alterations were accompanied by a decrease in the levels of GABA and increased levels of taurine in the epileptic animal. These data indicate that the deep SC of the GPG/Vall hamster is structurally abnormal; suggesting its involvement in the neuronal network for AGS.

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Midbrain substrates of audiogenic seizures in rats

Cited by 80 publications

References 61 publications

Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models

Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models

Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features

Morphologic and neurochemical alterations in the superior colliculus of the genetically epilepsy-prone hamster (GPG/Vall)

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