Middle-aged women with Turner's syndrome. Medical status, hormonal treatment and social life

Sylvén, Lisskulla; Hagenfeldt, Kerstin; Brøndum‐Nielsen, Karen; Schoultz, Bo von

doi:10.1530/acta.0.1250359

Cited by 83 publications

(74 citation statements)

References 8 publications

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“…One study found elevated levels of hepatic enzymes in 80% of middle-aged women with Turner syndrome, but could not associate the findings with overt hepatic disease (296). We found serum levels of alanine aminotransferase, g-glutamyl transferase, and total alkaline phosphatase to be higher in Turner patients compared with controls.…”

Section: Spontaneous Hepatic Functioncontrasting

confidence: 83%

“…How should a person with 5% (or less) 45,X cells and 95% 46,XX cells be considered, knowing that normally a karyotype is performed on Table 1 Detailed list of abnormalities associated with Turner syndrome with the tentative frequency of a specific abnormality given as a percentage. The table is compiled from different sources (8,55,178,296,305,307,321,350).…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological, endocrine and metabolic features in Turner syndrome

2004

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Turner syndrome is one of the more common genetic disorders, associated with abnormalities of the X chromosome, and occurring in about 50 per 100 000 liveborn girls. Turner syndrome is usually associated with reduced adult height, gonadal dysgenesis and thus insufficient circulating levels of female sex steroids, and infertility. A number of other signs and symptoms are seen more frequently with the syndrome. Morbidity and mortality are increased. The average intellectual performance is within the normal range. A number of recent studies have provided new insights with respect to epidemiology, cardiology, endocrinology and metabolism. Treatment with GH during childhood and adolescence allows a considerable gain in adult height, although verylong-term consequences of this treatment are not clear. Puberty has to be induced in most cases, and female sex hormone replacement therapy is given during the adult years. The proper dose of hormone replacement therapy (HRT) has not been established, and, likewise, benefits and/or drawbacks from HRT have not been thoroughly evaluated. Since the risk of cardiovascular and endocrinological disease is clearly elevated, proper care during adulthood is emphasized. In summary, Turner syndrome is a condition associated with a number of diseases and conditions which are reviewed in the present paper.

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Section: Spontaneous Hepatic Functioncontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Epidemiological, endocrine and metabolic features in Turner syndrome

2004

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“…The frequency of thyroid abnormalities increases with age in Turner syndrome as well as in the general population. The incidence of hypothyroidism due to Hashimoto's thyroiditis in adults with Turner syndrome was reported as 16-30% [1,4,[7][8][9]. In 2005, el-mansoury et al reported that the prevalence of hypothyroidism in Swedish adults with Turner syndrome was 25% in a large cohort study [8].…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Thyroid Diseases in 65 Japanese Women with Turner Syndrome

et al. 2009

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Abstract. Turner syndrome (TS) is associated with a number of complications including thyroid disease. In this study, the prevalence of thyroid disease was evaluated in Japanese women with TS. The medical charts of 65 TS women (age 30±9 years old, range: 15-61), treated with estrogen replacement therapy or with antiosteoporotic pharmaceuticals at our outpatient clinic, were reviewed. History of thyroid disease, titer of thyroid autoantibodies and thyroid function were recorded. Thyroid autoantibodies were undetectable in 28 of 65 women (43%), and thyroid function was normal in all these women. of the 37 women with thyroid autoantibodies (57%), 3 had Graves' disease and 20 women were hypothyroidism and diagnosed as Hashimoto's thyroiditis. The remaining 14 women with euthyroidism were also considered to be so-called probable cases of Hashimoto's thyroiditis. In 20 women with hypothyroidism, 14 (70%) received replacement therapy with levothyroxine. The replacement with levothyroxine started between age 17 and 60 (median: 31 years old). These data showed that more than half of Japanese women with TS in adulthood had thyroid autoantibodies. In women with TS, monitoring of thyroid hormone is important to detect hypothyroidism earlier and start adequate replacement therapy.

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“…Stature is short, and morbidity is increased due to risk of osteoporosis and fractures, type 2 diabetes, ischemic heart disease, hypertension, and stroke, but also the risk of cirrhosis is increased (1). Clinical studies have shown a frequent occurrence of elevated liver enzymes, primarily alanine aminotransferase (ALAT), g-glutamyl-transferase (gGT), and alkaline phosphatase (AP), while bilirubin is normal (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Quantitative liver functions in Turner syndrome with and without hormone replacement therapy

et al. 2007

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Background: Studies have documented elevated levels of liver enzymes in many females with Turner syndrome (TS). Histology has shown a range of changes. Treatment with female hormone replacement therapy (HRT) reduces liver enzymes. Aim: To study quantitative liver functions in TS in detail with and without HRT. Design: Randomized crossover study with active treatment (HRT in TS and P-pill in controls) or no treatment. Subjects: Women with TS (nZ8, age 29.7G5.6 (meanGS.D.) years), verified by karyotype, and agematched controls (C; nZ8, age 27.3G4.9 years). Methods: We determined liver enzymes in blood, used the galactose elimination capacity to assess hepatocyte cytosol activity, plasma clearance of indocyanine green to assess excretory function, antipyrine clearance to estimate microsomal activity, and the functional hepatic nitrogen clearance (FHNC) to assess mitochondrial-cytosolic metabolic capacity for conversion of amino-nitrogen. Results: Liver enzymes were elevated in untreated TS and reduced by HRT. The hepatic capacities for conversion of galactose, indocyanine green, and antipyrine were normal and did not change by HRT.

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Middle-aged women with Turner's syndrome. Medical status, hormonal treatment and social life

Abstract: A study of 49 middle-aged (>35 years old) women with Turner's syndrome was performed to evaluate medical status, hormonal treatment and social life. Most of the women lived a normal social life in stable

Cited by 83 publications

References 8 publications

Epidemiological, endocrine and metabolic features in Turner syndrome

Epidemiological, endocrine and metabolic features in Turner syndrome

Autoimmune Thyroid Diseases in 65 Japanese Women with Turner Syndrome

Quantitative liver functions in Turner syndrome with and without hormone replacement therapy

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