Middle ear cancer: A population‐based study

Gurgel, Richard K.; Hansen, Marlan R.

doi:10.1002/lary.20202

Cited by 39 publications

(48 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Richard first reported the prognosis of middle ear cancer using the SEER database [2], showing 5-year OS by stage, histology and treatment of patients diagnosed between 1973 and 2004. However, only univariate analysis was conducted in Richard’s study.…”

Section: Discussionmentioning

confidence: 99%

“…The most common tumors include squamous cell carcinoma (SCC), adenocarcinoma, basal cell carcinoma, adenoid cystic carcinoma, rhabdomyosarcoma, and Langerhans histocytosis X (LHX). Primary carcinoma of the middle ear represents a small subset of temporal bone carcinomas [2]. The incidence of middle ear cancer was approximately 0.18 per million people in the United States in 2011, according to the Surveillance Epidemiology and End Results (SEER) [3].…”

Section: Introductionmentioning

confidence: 99%

“…Because of the rarity of malignant tumors of the middle ear, most reports published previously were based on case series from a single institution, and most of the literature does not separate carcinomas of the external auditory canal from primary carcinomas of the middle ear [2]. The prognostic results therefore lack uniformity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic models to predict overall and cause-specific survival for patients with middle ear cancer: a population-based analysis

2014

View full text Add to dashboard Cite

BackgroundThe purpose of this study was to evaluate the survival outcome for middle ear cancer and to construct prognostic models to provide patients and clinicians with more accurate estimates of individual survival probability.MethodsPatients diagnosed with middle ear cancer between 1983 and 2011 were selected for the study from the Surveillance Epidemiology and End Results Program. We used the Kaplan-Meier product limit method to describe overall survival and cause-specific survival. Cox proportional hazards models were fitted to model the relationships between patient characteristics and prognosis. Nomograms for predicting overall survival and cause-specific survival were built using the Cox models established.ResultsThe entire cohort comprised 247 patients with malignant middle ear cancer. Median duration of follow-up until censoring or death was 25 months (range, 1–319 months). Five-year overall survival and cause-specific survival were 47.4% (95% Confidence Interval (CI), 41.2% to 54.6%) and 58.0% (95% CI, 51.6% to 65.3%), respectively. In multivariable analysis, age, histological subtype, stage, surgery and radiotherapy were predictive of survival. The bootstrap corrected c-index for model predicting overall and cause-specific survival was 0.73 and 0.74, respectively. Calibration plots showed that the predicted survival reasonably approximated observed outcomes.ConclusionThe models represent an objective analysis of all currently available data. The resulting models demonstrated good accuracy in predicting overall survival and cause-specific survival. Nomograms should thus be considered as a useful tool for predicting clinical prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic models to predict overall and cause-specific survival for patients with middle ear cancer: a population-based analysis

2014

View full text Add to dashboard Cite

show abstract

“…A population-based study of middle ear cancer revealed that histological subtypes include squamous cell carcinoma (62.8%), adenocarcinoma (18.2%), other carcinomas (13.0%), and noncarcinomas (6.0%). 7 In the patient in Case 1 (Fig. 1), the epidural tumor was located in the petrous and mastoid with bone destruction.…”

Section: Clinical and Radiological Differential Diagnoses For Intracrmentioning

confidence: 96%

Clinical, radiological, and pathological features of 26 intracranial and intraspinal malignant peripheral nerve sheath tumors

Ren

Wang

et al. 2013

JNS

View full text Add to dashboard Cite

Object Intracranial and intraspinal malignant peripheral nerve sheath tumors (MPNSTs) are rarely reported because of their extremely low incidence. Knowledge about these tumors is poor. In this study the authors aimed to analyze the incidence and clinical, radiological, and pathological features of intracranial and intraspinal MPNSTs. Methods Among 4000 cases of intracranial and intraspinal PNSTs surgically treated between 2004 and 2011 at Beijing Tiantan Hospital, cases of MPNST were chosen for analysis and were retrospectively reviewed. To determine which parameters were associated with longer progression-free survival (PFS) and overall survival (OS), statistical analysis was performed. Results Malignant PNSTs accounted for 0.65% of the entire series of intracranial and intraspinal PNSTs. Twenty-four (92.3%) of these 26 MPNSTs were primary. Radiologically, 26.9% (7 of 26) of the MPNSTs were misdiagnosed as nonschwannoma diseases. Twenty-one patients were followed up for 1.5 to 102 months after surgery. Twelve patients experienced tumor recurrence, and median PFS was 15.0 months. The 2- and 3-year PFS rates were 47.7% and 32.7%, respectively. Five patients died of tumor recurrence, and median OS was not available. The 2- and 3-year OS rates were 74.7% and 64.0%, respectively. Univariate analysis revealed that female sex, total tumor removal, and primary MPNSTs were significantly associated with a better prognosis. Multivariate analysis revealed that only total removal was an independent prognostic factor for both PFS and OS. Conclusions Malignant PNST within the skull or spinal canal is a rare neoplasm and is seldom caused by benign schwannomas. Radiologically, intracranial or intraspinal MPNST should be differentiated from meningioma, chordoma, fibrous dysplasia of bone, and ear cancer. Total resection whenever possible is necessary for the prolonged survival of patients, especially males.

show abstract

“…Middle ear carcinomas are a subset of temporal bone malignancies accounting for 0.2% of all head and neck cancer (1Y3). Several types have been described in the literature, such as adenocarcinoma, rhabdomyosarcoma, lymphoma, multiple myeloma, plasmocytoma, squamous cell carcinoma, mucoepidermoid carcinoma, and metastatic disease (1,2,4). Benign lesions such as inverted papilloma, probably ascending from the nasal cavity via the Eustachian tube, have been reported turning into carcinoma in the course of time (5).…”

mentioning

confidence: 99%

Giant Middle Ear Squamous Cell Carcinoma Mimicking as Cholesteatoma

Tomazic¹,

Ropposch²,

Karpf³

et al. 2012

Otology &Amp; Neurotology

View full text Add to dashboard Cite

Malignancies of the ear are rare findings, and mostly, they arise from the external auditory canal. Middle ear carcinomas are a subset of temporal bone malignancies accounting for 0.2% of all head and neck cancer (1Y3). Several types have been described in the literature, such as adenocarcinoma, rhabdomyosarcoma, lymphoma, multiple myeloma, plasmocytoma, squamous cell carcinoma, mucoepidermoid carcinoma, and metastatic disease (1,2,4). Benign lesions such as inverted papilloma, probably ascending from the nasal cavity via the Eustachian tube, have been reported turning into carcinoma in the course of time (5). Primary squamous cell carcinoma of the middle ear account for most lesions, with a rate of 62.9% as described by Gurgel et al.(2) in their study. However, they remain very rare compared with other head and neck carcinomas. The diagnosis is hampered by long symptom-free intervals or misdiagnosis as chronic otitis media.We report the case of a female patient referred to us with a diagnosis of chronic otitis media with cholesteatoma, which was identified histologically as giant squamous cell carcinoma. CASE REPORTA 56-year-old woman experiencing otorrhea for several months and progressive hearing loss was referred to our department with a diagnosis of chronic otitis media and cholesteatoma. The patient did not show any neurological deficits apart from a beginning facial nerve palsy. Microscopic examination of the ear revealed a signal polyp with an inflammatory thickened tympanic membrane. Pure-tone audiometry revealed a combined hearing loss, with a mean hearing loss of 101 dB on the right ear and an air-bone gap of 55 dB. A cholesteatoma was suspected and computed tomography and magnetic resonance contributed equally to this article.The authors have no financial or conflict of interest to disclose. FIG. 1. Preoperative axial computed tomographic scan showing a mass in the middle ear on the right side eroding the temporal bone (yellow circle). FIG. 2. Hematoxylin/eosinYstained slide of a tumor plug (white arrow) showing stromal invasion and desmoplastic stroma (intercepted white arrow) surrounding (original magnification, Â40).

show abstract

Middle ear cancer: A population‐based study

Cited by 39 publications

References 24 publications

Prognostic models to predict overall and cause-specific survival for patients with middle ear cancer: a population-based analysis

Prognostic models to predict overall and cause-specific survival for patients with middle ear cancer: a population-based analysis

Clinical, radiological, and pathological features of 26 intracranial and intraspinal malignant peripheral nerve sheath tumors

Giant Middle Ear Squamous Cell Carcinoma Mimicking as Cholesteatoma

Contact Info

Product

Resources

About